Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT04712266 | A Trial to Investigate Hyperglycemic and Hypoglycemic Excursions in Subjects With Type 1 Diabetes | EARLY_PHASE1 | COMPLETED | 15 | — | — | Sep 15, 2020 | Jan 10, 2021 | Jan 15, 2021 | 1 | United States |
\< 50mg/dl
\>150mg/dl
| Arm | Type | Description |
|---|---|---|
| Insulin IV | ACTIVE_COMPARATOR | calculated insulin rate |
| Insulin and Glucagon IV | EXPERIMENTAL | calculated molar ratio insulin:glucagon |
| Name | Type | Description |
|---|---|---|
| Glucagon | DRUG | calculated IV insulin:Glucagon molar ratio |
| Insulin | DRUG | calculated IV Insulin dose infused at a constant rate |
Inclusion Criteria: * Male or female patients aged between 18 and 64 years (both inclusive) * Type 1 diabetes mellitus (as diagnosed clinically) ≥ 12 months prior to the screening visit * Treated with daily insulin for T1DM ≥ 12 months prior to the screening visit Exclusion Criteria: \-