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Fluoxetine

Phase 1

Healthy | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Feb 21, 2011

Target and mechanism

ModalitySmall molecule

Also known as Fluoxetine Hydrochloride

Success Probability

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Market & Valuation

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Trial Design

RandomizedACTIVE_CONTROLLED
Total Trials2
Total Enrollment52

FDA Designations

No designations recorded

Clinical trial landscape

Fluoxetine · 2 trials · 1 indication

Phase 1 2
NCT0124727290 mg Fluoxetine Hydrochloride Capsules Under Fasting ConditionsHealthy
COMPLETED26 Analytics
NCT0124728590 mg Fluoxetine Hydrochloride Capsules Under Non-Fasting ConditionsHealthy
COMPLETED26 Analytics
PHASE1COMPLETED
90 mg Fluoxetine Hydrochloride Capsules Under Fasting Conditions
HealthyUnlock trial analytics
PHASE1COMPLETED
90 mg Fluoxetine Hydrochloride Capsules Under Non-Fasting Conditions
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Cmax of Fluoxetine.
Blood samples collected over a 25 day period.

Bioequivalence based on Fluoxetine Cmax (maximum observed concentration of drug substance in plasma).

AUC0-t of Fluoxetine.
Blood samples collected over a 25 day period.

Bioequivalence based on Fluoxetine AUC0-t (area under the concentration-time curve from time zero to time of last measurable concentration).

AUC0-inf of Fluoxetine.
Blood samples collected over a 25 day period.

Bioequivalence based on Fluoxetine AUC0-inf (area under the concentration-time curve from time zero to infinity).

Secondary Endpoints

Cmax of Norfluoxetine.
Blood samples collected over a 25 day period.
AUC0-t of Norfluoxetine.
Blood samples collected over a 25 day period.
AUC0-inf of Norfluoxetine.
Blood samples collected over a 25 day period.
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER

Treatment Arms

ArmTypeDescription
Reference Listed DrugACTIVE_COMPARATOR90 mg PROZAC WEEKLY® Capsules (Eli Lilly)
Investigational Test ProductEXPERIMENTAL90 mg Fluoxetine Hydrochloride Capsules (Teva)

Interventions

NameTypeDescription
Fluoxetine HydrochlorideDRUG90 mg Capsules
PROZAC WEEKLY®DRUG90 mg Capsules
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Screening Demographics: All volunteers selected for this study will be healthy men and women 18 years of age or older at the time of dosing. The weight range will not exceed + 15% for height and body frame as per Desirable Weights for Men - 1983 Metropolitan Height and Weight ...

Countries:United States
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