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TERN-601

Phase 2

Overweight or Obesity | Small molecule | Metabolic |Terns Pharmaceuticals, Inc.|Trials Updated: Nov 5, 2025

TERN-601 development status

Highest phase Phase 2
Registered trials 1 across 1 sponsor since Mar 2001

TERN-601 target and mechanism

Molecular targetGLP-1 receptor
Target classReceptor
ModalitySmall molecule

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment167

FDA Designations

No designations recorded

TERN-601 clinical trials

TERN-601 · 1 trial · 1 indication

Phase 2 1
NCT06854952A Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of TERN-601 in Adults With Overweight or ObesityOverweight or Obesity
COMPLETED167 Analytics
PHASE2COMPLETED
A Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of TERN-601 in Adults With Overweight or Obesity
Overweight or ObesityUnlock trial analytics

Study Design & Arms

Interventions

NameTypeDescription
TERN-601DRUGInvestigational drug
Matching PlaceboOTHERMatching placebo
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Frequently asked questions about TERN-601

What is TERN-601 used for?

TERN-601 is an investigational oral small molecule being developed for the treatment of overweight or obesity. It is a Phase 2 clinical-stage candidate from Terns Pharmaceuticals and has not been approved for any indication. It is being studied in adults with overweight or obesity.

What does TERN-601 target?

TERN-601 targets the GLP-1 receptor, a receptor that mediates the effects of glucagon-like peptide-1 on appetite and glucose regulation. By acting on this receptor, TERN-601 is designed as an oral small molecule GLP-1 receptor agonist for weight management in overweight or obesity.

Who makes TERN-601?

TERN-601 is being developed by Terns Pharmaceuticals, Inc., which trades on the Nasdaq under the ticker TERN. The company is the sponsor of the clinical program evaluating the drug in adults with overweight or obesity.

What phase is TERN-601 in?

TERN-601 is in Phase 2 clinical development. It is an investigational drug and has not been approved by the FDA or any other regulatory agency. The completed Phase 2 study enrolled 167 adults with overweight or obesity.

What clinical trials is TERN-601 in?

TERN-601 has been evaluated in the Phase 2 trial NCT06854952, titled A Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of TERN-601 in Adults With Overweight or Obesity. That study is listed as completed and enrolled 167 participants with overweight or obesity.