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Antihemophilic Factor Manufactured and Formulated without Added Human or Animal Proteins

Phase 2

Hemophilia A | Small molecule | Hematology |Takeda Pharmaceutical Company Limited|Last Updated: May 5, 2021

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment4

FDA Designations

No designations recorded

Clinical trial landscape

Antihemophilic Factor Manufactured and Formulated without Added Human or Animal Proteins · 1 trial · 1 indication

Phase 2 1
NCT00189982Efficacy and Safety Study of a Recombinant and Protein-Free Factor VIII (rAHF-PFM) in Pediatric Patients in Canada With Hemophilia A - A Continuation of Baxter Study 060101Hemophilia A
COMPLETED4 Analytics
PHASE2COMPLETED
Efficacy and Safety Study of a Recombinant and Protein-Free Factor VIII (rAHF-PFM) in Pediatric Patients in Canada With Hemophilia A - A Continuation of Baxter Study 060101
Hemophilia AUnlock trial analytics

Study Endpoints

Primary Endpoints

Assessment of safety, as measured by the incidence, causality, and severity of adverse experiences
Throughout the study period of approximately 23 months.

Secondary Endpoints

Assessment of the hemostatic efficacy in the treatment of bleeding episodes;
At least 50 exposure days or a total treatment time of 6 months, whichever came first.
assessment of the hemostatic efficacy in surgical or invasive procedures
From day of surgery until time of discharge from hospital or clinic (up to approximately 2 weeks post surgery).
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
Antihemophilic Factor Manufactured and Formulated without Added Human or Animal Proteins (rAHF-PFM)DRUGTreatment regimens were determined by the investigator, and may have been any combination of standard prophylaxis (25 to 50 IU/kg body weight, 3 to 4 times per week), investigator-determined prophylaxis, and/or on-demand treatment (dose selected by investigator). Once the treatment regimen was established, the regimen was to be maintained for the duration of the study, unless clinical reasons necessitated a change. The treatment of bleeding episodes and perioperative management was at the discretion of the investigator and consistent with the institution's standard of care.
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Eligibility Criteria

Age RangeN/A to 6 Years
SexMALE
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Subject must have participated and completed participation in Baxter's clinical study 060101 * Subject or parent/legally authorized representative has provided written informed consent Exclusion Criteria: * Subjects who have withdrawn from Baxter's Clinical Study 060101 prio...

Countries:Canada
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