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Thiocolchicoside+Ketoprofen

Phase 3

Low Back Pain | Small molecule | Musculoskeletal |Sanofi|Last Updated: Jun 11, 2010

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment334
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00679146Efficacy Safety of a Combination Thiocolchicoside+Ketoprofen Compared to Thiocolchicoside Twice a Day for 7 Days in Patients Suffering From Acute Non Specific Low Back PainPHASE3 COMPLETED 334Apr 1, 2008Jun 1, 2009Jun 11, 20106 Brazil, Colombia +4
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Study Endpoints
Primary Endpoints
Average pain within the last 24 hours (VAS)
at D3 visit
Secondary Endpoints
Average pain within the last 24 hours (VAS)
at D7 visit
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
1ACTIVE_COMPARATOR1 tablet TCC 8 mg + ketoprofen 100 mg b.i.d + 2 tablets TCC placebo b.i.d
2ACTIVE_COMPARATOR2 tablets TCC 4 mg b.i.d. + 1 tablet of FDC placebo b.i.d
Interventions
NameTypeDescription
Thiocolchicoside+KetoprofenDRUG1 tablet TCC 8 mg + ketoprofen 100 mg b.i.d + 2 tablets TCC placebo b.i.d
ThiocolchicosideDRUG2 tablets TCC 4 mg b.i.d. + 1 tablet of FDC placebo b.i.d
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Eligibility Criteria
Age Range20 Years — 55 Years
SexALL
Healthy VolunteersNo
Study Sites6

List of Inclusion and Exclusion criteria : Inclusion Criteria: * Non specific low back pain with an acute episode of recent onset (\<48 hours) defined by average pain within the last 24 hours equal or more than 50 mm on the Visual Analogue Scale (VAS) * Low back pain of diagnosis category 1 (low b...

Countries:BrazilColombiaEgyptGuatemalaMexicoVenezuela
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