Last updated
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R&D Expenses
Operating CF
Total Assets
Total Liabilities
Equity
Shares Out.
D/E Ratio
Dilution Watch
Financials
52W LOW $74.5052W HIGH $122.20
Volume
1.16 M
Value Traded
131.39 M
Short % Float
17.53%
Days to Cover
23.3
+0.95%Week
+30.75%1 Month
-0.36%3 Month
+32.45%6 Month
+305.73%5 Year
+278.46%All Time
Cash Data
- Monthly Burn
- Burn Trend
- Dilution Risk
- SEC Filing
Key Stats
Market Cap
7.88 B
EPS (TTM)
-2.81
P/E Ratio
-
Ent. Value
7.66 B
Total Shares
68.50 M
Float Shares
66.59 M
Insiders
3.96%
Institutions
109.90%
Upcoming Catalysts
FDA decisions, readouts and PDUFA dates · scored by probability of approval
PoA blends historical approval base rates, trial design score and FDA review track record.
RYTM Catalyst Timeline
Dated clinical, regulatory and corporate events for Rhythm Pharmaceuticals, Inc.
Catalyst Timeline
Dated clinical, regulatory & corporate events for Rhythm Pharmaceuticals, Inc.
547Total events
14Upcoming
150Tier-1 (high impact)
2017 to 2028Coverage
Upcoming catalysts 2
Event history 50
▲Partnership / LicenseCorporate
Amendment to existing HealthCare Royalty revenue interest financing agreement expected effective at term loan closing
●Debt Royalty FinancingCorporate
Initial $250 million draw under term loan facility expected at closing
▲Reimbursement / PricingSetmelanotideApprovedPost-Market
NICE issues positive guidance expanding IMCIVREE reimbursement to adults with BBS
Bardet-Biedl syndrome (BBS) in adultssource ↗
▲Partnership / LicenseBivamelagonCorporate
Rhythm amended LG Chem bivamelagon license, paying $350M to reduce royalty to 1%
▲Debt Royalty FinancingCorporate
Entered five-year term loan facility led by HealthCare Royalty with Blackstone Life Sciences
▲Product LaunchSetmelanotideApprovedPost-Market
Commercial launch of IMCIVREE in Japan for acquired HO
acquired hypothalamic obesitysource ↗
▲Canada ApprovalSetmelanotideApprovedEx-US Regulatory
Health Canada approved IMCIVREE for weight management in acquired HO
acquired hypothalamic obesitysource ↗
▲Poster PresentationSetmelanotideApprovedPresentation
Poster: Real-world BMI and hunger data for up to 18 months in paediatric acquired HO in France
acquired hypothalamic obesitysource ↗
●Oral PresentationSetmelanotideApprovedPresentation
Six setmelanotide abstracts presented at 64th ESPE Meeting
acquired hypothalamic obesitysource ↗
●Long Term DataSetmelanotideApprovedClinical Data
Oral/poster: Weight outcomes at 5-6 years of setmelanotide in paediatric POMC/LEPR deficiency or BBS
POMC or LEPR deficiency or Bardet-Biedl syndrome and obesitysource ↗
●Subgroup AnalysisSetmelanotideApprovedClinical Data
Post hoc analysis: Impact of setmelanotide on metabolic syndrome severity and risk score in acquired HO
acquired hypothalamic obesitysource ↗
●Poster PresentationPresentation
Poster: Association of clinical features of BBS in patients with obesity and biallelic BBS variants
Bardet-Biedl syndrome and obesitysource ↗
●R&D DayPresentation
Rhythm-sponsored expert-led satellite symposium at ESPE 2026
rare MC4R pathway diseasessource ↗
▲Oral PresentationSetmelanotideApprovedPresentation
Oral: Impact of setmelanotide on metabolic index scores in paediatric acquired HO (Phase 3 post-hoc)
acquired hypothalamic obesitysource ↗
▲Poster PresentationSetmelanotideApprovedPresentation
Poster: Real-world BMI and hunger data for up to 18 months in paediatric acquired HO in France
acquired hypothalamic obesitysource ↗
●Poster PresentationPresentation
Poster: Clinical features associated with pathogenic/likely pathogenic biallelic BBS gene variants in obesity population
Bardet-Biedl syndrome and obesitysource ↗
●R&D DayPresentation
Expert-led satellite symposium on advancing breakthrough therapy for rare MC4R pathway diseases at ESPE 2026
rare MC4R pathway diseasessource ↗
●Long Term DataSetmelanotideApprovedClinical Data
Oral/poster: Weight outcomes at 5-6 years of setmelanotide in paediatric POMC/LEPR deficiency or BBS
POMC or LEPR deficiency or Bardet-Biedl syndrome and obesitysource ↗
●Subgroup AnalysisSetmelanotideApprovedClinical Data
Post hoc analysis: Impact of setmelanotide on metabolic syndrome severity and risk score in acquired HO
acquired hypothalamic obesitysource ↗
▲Other Regulator MilestoneSetmelanotideApprovedEx-US Regulatory
MHLW grants marketing authorization to IMCIVREE for acquired hypothalamic obesity in Japan
acquired hypothalamic obesitysource ↗
▲Primary Endpoint MetSetmelanotideApprovedClinical Data
Phase 3 TRANSCEND trial met primary endpoint with -18.8% placebo-adjusted BMI reduction
acquired hypothalamic obesitysource ↗
▲PublicationSetmelanotideApprovedPresentation
Results from Phase 3 TRANSCEND trial published in The New England Journal of Medicine
acquired hypothalamic obesitysource ↗
▲Japan ApprovalSetmelanotideApprovedEx-US Regulatory
Japan MHLW approved IMCIVREE for acquired HO
acquired hypothalamic obesitysource ↗
▲Other Regulator MilestoneSetmelanotideApprovedEx-US Regulatory
MHRA grants expanded marketing authorization for IMCIVREE in UK
acquired hypothalamic obesitysource ↗
▲MHRA MilestoneSetmelanotideApprovedEx-US Regulatory
MHRA grants expanded marketing authorization for IMCIVREE in the UK
acquired hypothalamic obesity due to hypothalamic injury or impairmentsource ↗
▲UK Label ExpansionSetmelanotideApprovedEx-US Regulatory
IMCIVREE received expanded UK Marketing Authorization for acquired HO
acquired hypothalamic obesitysource ↗
▲Topline ReadoutRM-718Clinical Data
Preliminary data showed -11.6% mean BMI reduction at Week 16
acquired hypothalamic obesitysource ↗
●Quarterly UpdateSetmelanotideApprovedCorporate
Q2 2026 financial results and business update
▲Safety Data UpdateRM-718Clinical Data
RM-718 generally well tolerated; two mild hyperpigmentation cases
acquired hypothalamic obesitysource ↗
▼Trial DiscontinuedRM-718Trial
Two participants discontinued due to adverse events; one withdrew from extension
acquired hypothalamic obesitysource ↗
▲Japan ApprovalSetmelanotideApprovedEx-US Regulatory
Japan MHLW approved IMCIVREE (setmelanotide) for acquired hypothalamic obesity
acquired hypothalamic obesitysource ↗
●Enrollment UpdateRM-718Trial
Eleven patients enrolled; 8 remained on treatment as of July 16, 2026
acquired hypothalamic obesitysource ↗
▲Full ResultsSetmelanotideApprovedClinical Data
Phase 3 TRANSCEND trial results published in NEJM
acquired hypothalamic obesitysource ↗
▲PublicationSetmelanotideApprovedPresentation
NEJM publication of Phase 3 TRANSCEND trial results
acquired hypothalamic obesitysource ↗
◆Other Regulator MilestoneSetmelanotideApprovedEx-US Regulatory
Regulatory submission under review in Japan
acquired hypothalamic obesitysource ↗
▲Quarterly UpdateSetmelanotideApprovedCorporate
Q2 2026 net product revenue of $71.3 million from global sales of IMCIVREE
▲Poster PresentationBivamelagonPresentation
Weight Reduction After 1 Year of Oral Bivamelagon in Acquired Hypothalamic Obesity at ENDO 2026
Acquired Hypothalamic Obesitysource ↗
▲Poster PresentationSetmelanotideApprovedPresentation
Real-World Weight and Healthcare Utilization Outcomes with Setmelanotide in U.S. Patients with Bardet-Biedl Syndrome at ENDO 2026
Bardet-Biedl Syndromesource ↗
◆Poster PresentationSetmelanotideApprovedPresentation
Real-world outcomes in BBS: 6-month results from RESTORE poster at ENDO 2026
Bardet-Biedl syndromesource ↗
▲Oral PresentationSetmelanotideApprovedPresentation
Positive six-month data from Phase 2 trial of setmelanotide in PWS presented at ENDO 2026
Prader-Willi syndromesource ↗
◆Topline ReadoutSetmelanotideApprovedClinical Data
Six-month results from Phase 2 trial evaluating setmelanotide in patients with Prader-Willi syndrome announced on June 13, 2026
Prader-Willi Syndromesource ↗
▲Oral PresentationBivamelagonPresentation
Durable weight reduction after 1 year of bivamelagon treatment presented at ENDO 2026
acquired hypothalamic obesitysource ↗
◆Topline ReadoutRM-718Clinical Data
Results from Part C trial of RM-718 in acquired HO
acquired hypothalamic obesitysource ↗
●PublicationPresentation
Publication of diagnostic algorithm for BBS in American Journal of Medical Genetics
Bardet-Biedl syndromesource ↗
▲Oral PresentationSetmelanotideApprovedPresentation
Presentations at ECE 2026 including real-world efficacy in acquired HO
acquired hypothalamic obesitysource ↗
▲Poster PresentationSetmelanotideApprovedPresentation
Impact of Setmelanotide on Metabolic Index Scores in Phase 3 Trial Participants with Acquired Hypothalamic Obesity
acquired hypothalamic obesitysource ↗
▲Topline ReadoutSetmelanotideApprovedClinical Data
Interim six-month data from Phase 2 trial in PWS
Prader-Willi Syndromesource ↗
Past FDA Catalysts and PDUFA Decisions
How RYTM actually traded into and out of each decision
| Date | Drug | Catalyst | Stage | Reaction | Event Move % | Best Trade % |
|---|---|---|---|---|---|---|
| 2026-09-08 | setmelanotide (IMCIVREE) | Phase 3 data readout | Phase 3 |
Reaction: 30 trading days around the event · Event Move: close to close on decision day · Best Trade: peak run-up from entry 10 days before the decision
Drug Pipeline Intelligence
Pipeline Score
Pipeline Value
Commercial Value
Valuation Signal
3
Drugs Scored
rNPV / MCap
Top Drug
Top 35%
Small Cap(rank 242 of 689)
Percentile Rank
Commercial products (revenue basis: trailing 4 quarters of total revenue (10-K and 10-Q), to Sep 2026; product lines: last four quarters to Sep 2026 (10-K and 10-Q))
| Product | Revenue | Prior period | Change |
|---|---|---|---|
| IMCIVREE |
| Drug | Indication | Phase | PTRS | rNPV | Status | Enroll | Velocity | Design | Est. Completion | ML Signal | Last Change |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Setmelanotide PeptidesMarketedNCT05774756 | Hypothalamic Obesity | Approved | ACTIVE NOT_RECRUITING | 200 | Apr 16, 2027 | ||||||
| Setmelanotide PeptidesNCT06772597 | Prader-Willi Syndrome | Phase 2 | ACTIVE NOT_RECRUITING | 58 | Oct 30, 2030 | ||||||
| RM-718 Small MoleculesNCT06239116 | Hypothalamic Obesity | Phase 1/2 | ACTIVE NOT_RECRUITING | 111 | Nov 1, 2028 | ||||||
| Setmelanotide PeptidesMarketedNCT05093634 | Obesity | Approved | COMPLETED | 296 | Jun 30, 2026 | ||||||
| Setmelanotide PeptidesMarketedNCT04966741 | Bardet-Biedl Syndrome | Approved | COMPLETED | 83 | Nov 8, 2024 | ||||||
| Setmelanotide PeptidesMarketedNCT03287960 | Leptin Receptor Deficiency Obesity | Approved | COMPLETED | 15 | Sep 25, 2020 | ||||||
| Setmelanotide PeptidesNot countedNCT03651765 | Obesity Associated With Defects in Leptin-melanocortin Pathway | Phase 3 | COMPLETED | 233 | Jan 9, 2025 | ||||||
| Setmelanotide PeptidesMarketedNCT02896192 | Pro-opiomelanocortin (POMC) Deficiency Obesity | Approved | COMPLETED | 15 | May 25, 2020 | ||||||
| Setmelanotide PeptidesMarketedNCT04963231 | Genetic Obesity | Approved | COMPLETED | 377 | Sep 30, 2024 | ||||||
| Setmelanotide PeptidesNot countedNCT02041195 | Overweight and Obesity | Phase 1/2 | COMPLETED | 99 | Dec 1, 2014 | ||||||
| Setmelanotide PeptidesNot countedNCT01749137 | Overweight | Phase 2 | COMPLETED | 74 | Sep 28, 2013 | ||||||
| Setmelanotide PeptidesNot countedNCT03262610 | Hypertriglyceridemia | Phase 2 | COMPLETED | 1 | Jan 31, 2018 | ||||||
| Setmelanotide PeptidesNot countedNCT04348175 | Renal Insufficiency | Phase 1 | COMPLETED | 32 | Apr 17, 2021 | ||||||
| Bivamelagon Small MoleculesNCT06046443 | Hypothalamic Obesity | Phase 2 | COMPLETED | 53 | Feb 9, 2026 | ||||||
| RM-493 PeptidesMarketedNCT01867437 | Obesity | Approved | COMPLETED | 15 | Mar 1, 2014 | ||||||
| RM-493 PeptidesNot countedNCT02431442 | Overweight | Phase 1 | COMPLETED | 57 | Jan 1, 2014 |
Clinical Trial Results
Readouts, endpoints and source filings for every RYTM program
| Drug Name | Indication | Phase | Date | Trial Results Summary | Title | Source |
|---|---|---|---|---|---|---|
| setmelanotide BreakthroughPriorityOrphan | acquired hypothalamic obesity | Phase 3 | 2026-09-10 | -11.5% reduction in mean BMI from baseline (p <0.0001) in patients who reached 6 months (n=17); -13.4% reduction in mean BMI from baseline (p <0.001) in patients who reached 9 months (n=14); -10.5% reduction in mean BMI from baseline (p <0.01) in patients who reached 12 months (n=13); -9.0% reduction in BMI from baseline (p<0.13) in patients who reached 18 months (n=5); More than 88% of patients achieved a ≥0.2-point reduction in BMI z-score after 6, 9, or 12, and 18 months of treatment; 100% of patients achieving ≥0.2-point reduction in BMI z-score at 12 months (n=13) and 18 months (n=5); Metabolic syndrome z-BMI score mean change was -0.8 vs -0.2 for the placebo group (p=0.006) (n=35 vs n=19); The mean change in Lipid Accumulation Product (LAP) (n=41 vs n=22) from baseline was -25.6 compared with +3.6 for the placebo group (p<0.0001); The mean change in Triglyceride-Glucose Waist Circumference Index (TyG-WC) (n=38 vs n=22) was -116.8 vs +34.0 for the placebo group (p<0.0001)Read More | Rhythm Pharmaceuticals Announces New Data Presentations at the European Society for Paediatric Endocrinology MeetingRead More |
Inside Trades
| Insider | Side | Shares | Price | Value | Date |
|---|---|---|---|---|---|
| Meeker David PDirector, Officer (President and CEO) | Option | 50,000 289,258 held | $6.05 | 09/14/2026 |
Hedge Fund 13F Activity
Hedge Funds invested in RYTM
| Fund | % of Portfolio | Current MV | Shares Owned | Activity |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 6.4 % (4.9 %) | 740.22 M | 6.67 M |
Ownership Trends
RYTM Short Interest
Shares sold short, counted twice a month.
17.53%
Short % of Float
of tradable shares sold short
11.7M
Shares Sold Short
+6.1% vs prior count
23.3 Very high
Days to Cover
trading days of normal volume to buy every short share back
500.5K
Avg Daily Volume
the average used for days to cover
Options Data
Option Volume
Open Interest
Call OI
Put OI
Put-Call Ratio
OI 30-day avg
Today vs avg
Option Volume
Call Vol
Put Vol
Put-Call Ratio
Vol 30-day avg
Today vs avg
Option Chain Statistics
| Expiry | Call Vol | Put Vol | Vol P/C | Call OI | Put OI | OI P/C | IV Call | IV Call OI-Wtd | IV Call Vol-Wtd | IV Put | IV Put OI-Wtd | IV Put Vol-Wtd |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026-11-20 | ||||||||||||
Real-Time Option Chain
| Calls | Strike | Puts | ||||
|---|---|---|---|---|---|---|
| Last | Vol | OI | Last | Vol | OI | |
| No data available | ||||||
Calls vs Puts by Expiry
CallsPutsLog scale
Competitive positioning
How RYTM ranks across every disease it competes in
Competitive Position is a premium feature
See how RYTM ranks against every competitor across each disease it develops in: phase, best drug, trials and likelihood of approval.
Start free trialRYTM News
RYTM▲ +28%on this news
Rhythm Pharmaceuticals Announces NICE Guidance for IMCIVREE® (Setmelanotide) Updated to Include Adults Living with Bardet-Biedl Syndrome
Rhythm Pharmaceuticals announced that NICE has updated its guidance for IMCIVREE (setmelanotide) to include adults with genetically confirmed Bardet-Biedl syndrome. This change allows these adults to access funded treatment through the NHS, expanding upon previous recommendations for younger patients. The decision was based on additional evidence highlighting the burden of hyperphagia and obesity associated with the syndrome.
Read more →RYTM▼ -7.5%on this news· ran to +20% by day 3shared move
Rhythm Pharmaceuticals Reports Third Quarter 2026 Financial Results and Business Update
Rhythm Pharmaceuticals reported a strong third quarter for 2026, with net product revenue from IMCIVREE reaching $92.1 million, a 29% increase from the previous quarter. The company is expanding its market presence with the launch of IMCIVREE in Japan and plans to advance bivamelagon into pivotal trials for Prader-Willi syndrome. Management expressed confidence in the growth potential of their product portfolio.
Read more →RYTM▼ -7.5%on this news· ran to +20% by day 3shared move
Rhythm Pharmaceuticals and LG Chem Enter into Amendment to Bivamelagon Exclusive License Agreement
Rhythm Pharmaceuticals announced an amendment to its licensing agreement with LG Chem for bivamelagon, reducing royalties to 1% on global net sales. The company will pay LG Chem an additional $350 million over four years. Rhythm also secured a $750 million term loan facility to support this agreement and its commercialization efforts.
Read more →RYTMRhythm Pharmaceuticals to Report Third Quarter 2026 Financial Results on Tuesday, November 3, 2026
Rhythm Pharmaceuticals will host a conference call on November 3, 2026, to discuss its Q3 financial results. The company will also participate in investor conferences on November 9 and 11, 2026. Rhythm's lead product, setmelanotide, is approved for treating rare neuroendocrine diseases and obesity-related conditions.
Read more →RYTMRhythm Pharmaceuticals Announces Commercial Launch of IMCIVREE® (setmelanotide) in Japan for Patients with Acquired Hypothalamic Obesity
Rhythm Pharmaceuticals has launched IMCIVREE (setmelanotide) in Japan for acquired hypothalamic obesity, following its approval by the Ministry of Health, Labour and Welfare. This marks the first approved treatment for this condition in Japan. The launch is supported by data from a pivotal Phase 3 trial demonstrating significant efficacy in reducing body mass index.
Read more →RYTMRhythm Pharmaceuticals Announces Health Canada Approval of IMCIVREE® (setmelanotide) for Weight Management in Adult and Pediatric Patients 4 years of Age and Older with Acquired Hypothalamic Obesity
Rhythm Pharmaceuticals has received Health Canada approval for IMCIVREE (setmelanotide) to manage weight in patients aged 4 and older with acquired hypothalamic obesity. This approval follows the drug's initial approval for obesity due to Bardet-Biedl syndrome. The decision is based on positive results from the Phase 3 TRANSCEND trial, which demonstrated significant weight loss in participants.
Read more →RYTMRhythm Pharmaceuticals Announces New Data Presentations at the European Society for Paediatric Endocrinology Meeting
Rhythm Pharmaceuticals presented new data at the European Society for Paediatric Endocrinology Meeting, highlighting the efficacy of setmelanotide in treating acquired hypothalamic obesity in pediatric patients. Real-world data showed significant reductions in BMI and hunger scores over 18 months. Additionally, Phase 3 analyses indicated improvements in various cardiometabolic risk indices, supporting the treatment's potential benefits.
Read more →RYTMRhythm Pharmaceuticals Announces MHLW Approval of IMCIVREE® (setmelanotide) for Patients with Acquired Hypothalamic Obesity (HO) in Japan
Rhythm Pharmaceuticals has received marketing authorization from Japan's MHLW for IMCIVREE (setmelanotide) to treat acquired hypothalamic obesity (HO). This approval marks the first therapy for this condition in Japan, with a commercial launch expected by the end of 2026, pending pricing. The decision is supported by positive results from the Phase 3 TRANSCEND trial.
Read more →RYTMRhythm Pharmaceuticals Announces Appointment of Manher (AJ) Joshi as Chief Medical Officer
Rhythm Pharmaceuticals has appointed Dr. Manher 'AJ' Joshi as Chief Medical Officer, effective August 17, 2026. Dr. Joshi brings over two decades of experience in biopharmaceutical development, which will aid Rhythm's growth and focus on rare neuroendocrine diseases. The company aims to enhance its leadership in this field and advance its clinical pipeline.
Read more →RYTMRhythm Pharmaceuticals Announces IMCIVREE® (setmelanotide) Receives Expanded Marketing Authorization in the United Kingdom for Treatment of Obesity and Control of Hunger in Patients with Acquired Hypothalamic Obesity due to Hypothalamic Injury or Impairment
Rhythm Pharmaceuticals announced that the UK regulator expanded IMCIVREE authorization for acquired hypothalamic obesity. The approval covers adults and children aged four and older with this condition. Clinical data showed a 19.8 percent placebo-adjusted reduction in body mass index. The drug also reduced hunger symptoms in patients during the trial period.
Read more →RYTMRhythm Pharmaceuticals Announces Participation in Upcoming Investor Conferences
Rhythm Pharmaceuticals announced that its CEO David Meeker and CFO Hunter Smith will participate in fireside chats at three upcoming investor conferences. These events include the Canaccord Genuity 46th Annual Growth Conference, the Wells Fargo 21st Annual Healthcare Conference, and the Morgan Stanley 24th Annual Global Healthcare Conference. The discussions will be webcasted, allowing wider access to the company's updates.
Read more →RYTMRhythm Pharmaceuticals Reports Second Quarter 2026 Financial Results and Business Update
Rhythm Pharmaceuticals reported strong financial results for Q2 2026, with net product revenue from IMCIVREE reaching $71.3 million. The U.S. launch of IMCIVREE for acquired hypothalamic obesity has seen over 400 patient start forms since FDA approval. Positive clinical trial results and upcoming launches in Japan and Europe are expected to drive further growth.
Read more →RYTMRhythm Pharmaceuticals Announces Preliminary Data from Phase 2 Trial that Showed RM-718 Demonstrated Positive Efficacy Signal in Acquired Hypothalamic Obesity
Rhythm Pharmaceuticals announced preliminary data from its Phase 2 trial of RM-718, an MC4R agonist for acquired hypothalamic obesity. The trial showed a significant mean BMI reduction of 11.6% after 16 weeks. The results are comparable to existing treatments, with limited adverse effects reported. Management will discuss these findings in a conference call.
Read more →RYTMRhythm Pharmaceuticals to Report Second Quarter 2026 Financial Results on Tuesday, August 4, 2026
Rhythm Pharmaceuticals will host a live conference call on August 4, 2026, to report its second quarter financial results and provide a corporate update. The company focuses on rare neuroendocrine diseases and has received FDA and European Commission approvals for its lead product, setmelanotide. The call will be accessible via their website, with an archived version available for 30 days.
Read more →RYTMRhythm Pharmaceuticals Announces The New England Journal of Medicine Publication of Phase 3 TRANSCEND Trial Results in Acquired Hypothalamic Obesity
Rhythm Pharmaceuticals announced the publication of Phase 3 TRANSCEND trial results in The New England Journal of Medicine. The trial demonstrated significant weight loss and hunger reduction in patients with acquired hypothalamic obesity treated with setmelanotide. The FDA has approved setmelanotide as the first therapy for this condition, highlighting its potential impact on patient care.
Read more →RYTMRhythm Pharmaceuticals Announces Multiple New Data Presentations from MC4R Agonists in Acquired Hypothalamic Obesity (HO), Bardet-Biedl Syndrome (BBS) and Prader-Willi Syndrome (PWS) at ENDO 2026
Rhythm Pharmaceuticals presented new data at ENDO 2026, showcasing the effectiveness of MC4R agonists, particularly setmelanotide and bivamelagon, in treating acquired hypothalamic obesity (HO), Bardet-Biedl syndrome (BBS), and Prader-Willi syndrome (PWS). The data revealed significant weight loss and improvements in hunger measures, with a focus on long-term efficacy and real-world outcomes. However, some adverse events were reported, including nausea and hypersensitivity reactions.
Read more →RYTMRhythm Pharmaceuticals Presents Positive Interim Six-month Data from Phase 2 Trial of Setmelanotide in Patients with Prader-Willi Syndrome (PWS) at ENDO 2026
Rhythm Pharmaceuticals presented positive interim data from a Phase 2 trial of setmelanotide for Prader-Willi syndrome (PWS) at ENDO 2026. The results showed significant reductions in BMI and fat mass, alongside improvements in hyperphagia and anxiety. These findings support the rationale for advancing to Phase 3 trials. The ongoing study includes 17 patients, with promising outcomes noted at the six-month mark.
Read more →RYTMRhythm Pharmaceuticals to Announce Interim Six-Month Phase 2 Results Evaluating Setmelanotide in Patients with Prader-Willi Syndrome
Rhythm Pharmaceuticals will announce interim results from its Phase 2 trial of setmelanotide in patients with Prader-Willi syndrome on June 13, 2026. The conference call will feature insights from company executives and a pediatric endocrinologist. Setmelanotide is already approved for certain obesity-related conditions, highlighting its potential impact on rare diseases.
Read more →RYTM▼ -5%on this news
Rhythm Pharmaceuticals Announces Seven Abstracts Accepted for Presentation at ENDO 2026
Rhythm Pharmaceuticals announced that seven abstracts, including four late-breaking ones, have been accepted for presentation at ENDO 2026, scheduled for June 13-16, 2026. Key presentations will focus on the efficacy of setmelanotide in treating Prader-Willi syndrome and acquired hypothalamic obesity. The company will also host its inaugural MOMENTUM meeting to discuss advancements in MC4R pathway diseases.
Read more →RYTMRhythm Pharmaceuticals Announces Publication of New Bardet-Biedl Syndrome Diagnostic Algorithm in the American Journal of Medical Genetics
Rhythm Pharmaceuticals announced the publication of a new diagnostic algorithm for Bardet-Biedl syndrome (BBS) in the American Journal of Medical Genetics. This evidence-based algorithm aims to simplify and expedite the diagnosis of BBS, integrating advances in genetic testing and clinical understanding. It is designed to assist healthcare practitioners in making timely diagnoses across various clinical presentations.
Read more →About Rhythm Pharmaceuticals, Inc.
Headquarters222 BERKELEY STREET, BOSTON, MA, 02116
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