Recent Updates
Recently added Catalysts

SPK-8011QQ

Phase 1

Hemophilia A | Small molecule | Hematology |Roche Holding AG|Last Updated: Aug 4, 2026

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

UNCONTROLLEDDMC
Total Trials1
Total Enrollment5

FDA Designations

No designations recorded

Clinical trial landscape

SPK-8011QQ · 1 trial · 1 indication

Phase 1 1
NCT07226206A Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia AHemophilia A
RECRUITING5 Analytics
PHASE1RECRUITING
A Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia A
Hemophilia AUnlock trial analytics

Study Endpoints

Primary Endpoints

Incidence of participants with adverse events (AEs)
Up to approximately 5 years
Severity of AEs as determined according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) v5.0 grading scale
Up to approximately 5 years
Incidence of adverse events of special interest (AESIs)
Up to approximately 5 years
Incidence of serious adverse events (SAEs)
Up to approximately 5 years
Incidence of treatment-related AEs
Up to approximately 5 years
Number of participants with abnormal laboratory values
Up to approximately 5 years
Unlock Study Endpoints

Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
SPK-8011QQEXPERIMENTALParticipants will receive an intravenous (IV) infusion of SPK-8011QQ on Day 1 of the study.

Interventions

NameTypeDescription
SPK-8011QQDRUGParticipants will receive IV SPK-8011QQ
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to N/A
SexMALE
Healthy VolunteersNo
Study Sites3

Inclusion Criteria: * Signed Informed Consent Form (ICF) * ≥18 years of age at the time of signing the ICF * Male sex assigned at birth * Severe or moderately severe hemophilia A, defined as endogenous FVIII:C activity levels ≤3%, as documented (historically or during the Screening Period) by a cer...

Countries:United States
Unlock Eligibility Criteria

Recent Changes (Last 90 Days)

LOWAug 4, 2026NCT07226206startDate: changed
LOWAug 4, 2026NCT07226206startDate: changed
LOWAug 1, 2026NCT07226206startDate: changed
LOWAug 1, 2026NCT07226206startDate: changed
LOWAug 1, 2026NCT07226206startDate: changed

Frequently asked questions about SPK-8011QQ

What is SPK-8011QQ used for?

SPK-8011QQ is an investigational gene therapy being studied for the treatment of hemophilia A, specifically in adults with severe or moderately severe forms of the condition. It is currently in Phase 1 clinical development and is not yet approved by regulatory authorities.

Who makes SPK-8011QQ?

SPK-8011QQ is being developed by Roche Holding AG, a multinational healthcare company. Roche's stock is traded under the ticker symbol RHHBY on the OTC market. The drug is currently in Phase 1 clinical trials for hemophilia A.

What phase is SPK-8011QQ in?

SPK-8011QQ is in Phase 1 clinical development. It is an investigational drug being studied for the treatment of hemophilia A. The drug is not yet approved and is currently being evaluated in an early-stage clinical trial to assess its safety and potential efficacy.

What clinical trials is SPK-8011QQ in?

SPK-8011QQ is being studied in a Phase 1 clinical trial with the identifier NCT07226206. This trial is titled 'A Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia A' and is currently recruiting participants in the United States. The trial is an uncontrolled, open-label study with an enrollment target of 5 male participants aged 18 years and older.

Is SPK-8011QQ FDA approved?

SPK-8011QQ is not FDA approved. It is an investigational drug currently in Phase 1 clinical development for the treatment of hemophilia A. The drug is being studied in a clinical trial to evaluate its safety and potential benefits, but it has not yet received regulatory approval for commercial use.