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EYU688

Phase 2

Dengue | Small molecule | Infectious Disease |Novartis AG|Last Updated: Aug 19, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment108

FDA Designations

No designations recorded

Clinical trial landscape

EYU688 · 1 trial · 1 indication

Phase 2 1
NCT06006559A Study to Assess the Efficacy, Safety and Pharmacokinetics of EYU688 in Patients With Dengue FeverDengue
RECRUITING108 Analytics
PHASE2RECRUITING
A Study to Assess the Efficacy, Safety and Pharmacokinetics of EYU688 in Patients With Dengue Fever
DengueUnlock trial analytics

Study Endpoints

Primary Endpoints

Viremia reduction (viral load reduction (VLR) on log scale) at 48 hours post treatment start
From predose to 48 hours post treatment start

Efficacy assessment of EYU688. It will allow to quantify the viremia reduction at 48 hours post treatment start from baseline.

Secondary Endpoints

Time from fever onset to start of the first 48 hours period during which the oral temperature remained below 37.5℃
From fever onset to Day 15
Time from fever onset to the first of two consecutive negative viremia by PCR
From fever onset to Day 15
Area under the log-transformed viremia curve (AUC) from the first dose to Day 15
From fever onset to Day 15
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
EYU688EXPERIMENTALEYU688 administered by oral route
PlaceboPLACEBO_COMPARATORMatching placebo

Interventions

NameTypeDescription
EYU688DRUGEYU688 administered by oral route
PlaceboDRUGMatching placebo administered orally as capsules
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Eligibility Criteria

Age Range18 Years to 60 Years
SexALL
Healthy VolunteersNo
Study Sites27

Inclusion Criteria: * Male or female, 18 - 60 years old (inclusive). * History or presence of fever (≥ 38°C). At least one of the following criteria indicating dengue infection: * Nausea or vomiting. * Presence of rash, aches or pains including headache, muscle or joint pain. * Onset of fever ≤ 48 ...

Countries:BrazilColombiaIndiaMalaysiaMexicoSingaporeVietnam
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Recent Changes (Last 90 Days)

LOWAug 20, 2026NCT06006559lastUpdatePostDate: changed
LOWAug 20, 2026NCT06006559lastUpdatePostDate: changed
LOWAug 20, 2026NCT06006559lastUpdatePostDate: changed
LOWAug 20, 2026NCT06006559lastUpdatePostDate: changed
MEDIUMJul 15, 2026NCT06006559primaryCompletionDate: changed
MEDIUMJul 15, 2026NCT06006559primaryCompletionDate: changed

Frequently asked questions about EYU688

What is EYU688 used for?

EYU688 is an investigational small molecule being developed for the treatment of dengue fever. It is currently in Phase 2 clinical development and has not been approved by regulatory authorities. The drug is being studied in patients with dengue to assess its efficacy, safety, and pharmacokinetics.

Who makes EYU688?

EYU688 is being developed by Novartis AG, a multinational pharmaceutical company listed on the New York Stock Exchange under the ticker symbol NVS. The company is conducting clinical trials to evaluate the drug's potential as a treatment for dengue fever.

What phase is EYU688 in?

EYU688 is currently in Phase 2 clinical development. It is an investigational drug, meaning it has not yet been approved by the FDA or other regulatory agencies. The ongoing Phase 2 trial is designed to evaluate the drug's efficacy, safety, and pharmacokinetics in patients with dengue fever.

What clinical trials is EYU688 in?

EYU688 is being evaluated in a Phase 2 clinical trial with the identifier NCT06006559. This randomized, double-blind, placebo-controlled study is recruiting 108 participants aged 18 years and older with dengue fever. The trial is being conducted across multiple countries, including Brazil, Colombia, India, Malaysia, Mexico, Singapore, and Vietnam.

Is EYU688 FDA approved?

EYU688 is not FDA approved. It is an investigational drug currently in Phase 2 clinical trials for the treatment of dengue fever. The drug is being studied to determine its safety and efficacy, and it has not yet received marketing authorization from the FDA or any other regulatory body.

How does EYU688 work?

EYU688 is a small molecule being developed by Novartis for the treatment of dengue fever. The specific molecular target of EYU688 has not been disclosed in available information. The drug is currently being evaluated in a Phase 2 clinical trial to assess its efficacy, safety, and pharmacokinetics in patients with dengue.