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LY4226695

Phase 1

Undisclosed | Small molecule | Other |Eli Lilly and Company|Trials Updated: Sep 22, 2026

LY4226695 development status

Highest phase Phase 1
Registered trials 1 across 1 sponsor since Aug 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment148

FDA Designations

No designations recorded

LY4226695 clinical trials

LY4226695 · 1 trial · 1 indication

Phase 1 1
NCT07767487A Study of LY4226695 in Healthy ParticipantsHealthy
RECRUITING148 Analytics
PHASE1RECRUITING
A Study of LY4226695 in Healthy Participants
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline through Day 57

Secondary Endpoints

Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of LY4226695
Baseline through Day 57
PK: Maximum Concentration (Cmax) of LY4226695
Baseline through Day 57
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY4226695 Part AEXPERIMENTALParticipants will receive LY4226695 or placebo administered subcutaneously (SC)
LY4226695 Part BEXPERIMENTALParticipants will receive LY4226695 or placebo administered SC
LY4226695 Part CEXPERIMENTALParticipants will receive LY4226695 or placebo administered SC
LY4226695 Part DEXPERIMENTALParticipants will receive LY4226695 administered intravenously (IV)

Interventions

NameTypeDescription
LY4226695DRUGAdministered SC
PlaceboDRUGAdministered SC
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Eligibility Criteria

Age Range22 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Have a screening body mass index (BMI) in the range of 18.5 to 35 kilograms per square meter (kg/m²), inclusive, with no significant weight gain or loss in the past 3 months prior to screening. * Individuals assigned male at birth must agree to adhere to contraception restrict...

Countries:United StatesSingapore
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Recent Changes (Last 90 Days)

LOWSep 22, 2026NCT07767487Status: NOT_YET_RECRUITING → RECRUITING
LOWSep 22, 2026NCT07767487Status: NOT_YET_RECRUITING → RECRUITING
LOWAug 17, 2026NCT07767487NEW_TRIAL: changed
LOWAug 17, 2026NCT07767487NEW_TRIAL: changed

Frequently asked questions about LY4226695

What is LY4226695?

LY4226695 is an investigational small molecule being developed by Eli Lilly and Company. It is currently in Phase 1 clinical development, with a single recruiting study in healthy participants. No therapeutic indication has been disclosed for the compound.

Who is developing LY4226695?

LY4226695 is being developed by Eli Lilly and Company, which trades on the New York Stock Exchange under the ticker LLY. Lilly is the sponsor of the Phase 1 study evaluating the compound in healthy participants.

What phase is LY4226695 in?

LY4226695 is in Phase 1 clinical development. It has one active, recruiting trial and no completed trials. The compound is investigational and has not been approved by the FDA for any indication.

What clinical trials is LY4226695 in?

LY4226695 is being evaluated in a single Phase 1 trial, NCT07767487, titled A Study of LY4226695 in Healthy Participants. The study is recruiting, is randomized, double-blind, and controlled, and plans to enroll 148 healthy volunteers in the United States and Singapore.

Who can enroll in the LY4226695 Phase 1 trial?

The NCT07767487 trial enrolls healthy volunteers of all sexes who are at least 22 years old. It is a randomized, double-blind, controlled Phase 1 study with a planned enrollment of 148 participants across sites in the United States and Singapore.