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LY4226695

Phase 1

Healthy | Small molecule | Other |Eli Lilly and Company|Last Updated: Aug 17, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment148

FDA Designations

No designations recorded

Clinical trial landscape

LY4226695 · 1 trial · 1 indication

Phase 1 1
NCT07767487A Study of LY4226695 in Healthy ParticipantsHealthy
NOT YET_RECRUITING148 Analytics
PHASE1NOT YET_RECRUITING
A Study of LY4226695 in Healthy Participants
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline through Day 57

Secondary Endpoints

Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of LY4226695
Baseline through Day 57
PK: Maximum Concentration (Cmax) of LY4226695
Baseline through Day 57
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY4226695 Part AEXPERIMENTALParticipants will receive LY4226695 or placebo administered subcutaneously (SC)
LY4226695 Part BEXPERIMENTALParticipants will receive LY4226695 or placebo administered SC
LY4226695 Part CEXPERIMENTALParticipants will receive LY4226695 or placebo administered SC
LY4226695 Part DEXPERIMENTALParticipants will receive LY4226695 administered intravenously (IV)

Interventions

NameTypeDescription
LY4226695DRUGAdministered SC
PlaceboDRUGAdministered SC
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Eligibility Criteria

Age Range22 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Have a screening body mass index (BMI) in the range of 18.5 to 35 kilograms per square meter (kg/m²), inclusive, with no significant weight gain or loss in the past 3 months prior to screening. * Individuals assigned male at birth must agree to adhere to contraception restrict...

Countries:United StatesSingapore
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Recent Changes (Last 90 Days)

LOWAug 17, 2026NCT07767487NEW_TRIAL: changed
LOWAug 17, 2026NCT07767487NEW_TRIAL: changed

Frequently asked questions about LY4226695

What is LY4226695 used for?

LY4226695 is an investigational small molecule being studied in healthy participants. It is currently in Phase 1 clinical development, with a single trial evaluating its effects in healthy volunteers. The drug is not approved for any indication and remains under investigation.

Who makes LY4226695?

LY4226695 is being developed by Eli Lilly and Company, a biopharmaceutical company traded on the NYSE under the ticker LLY. The company is conducting a Phase 1 clinical trial of this small molecule in healthy participants.

What phase is LY4226695 in?

LY4226695 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities. The ongoing Phase 1 trial is designed to study the drug in healthy participants and is not yet recruiting.

What clinical trials is LY4226695 in?

LY4226695 is being studied in a single Phase 1 clinical trial with the identifier NCT07767487. The trial, titled 'A Study of LY4226695 in Healthy Participants,' is expected to enroll 148 participants and is conducted in the United States and Singapore.

Is LY4226695 FDA approved?

LY4226695 is not FDA approved. It is an investigational small molecule currently in Phase 1 clinical development. The drug is being studied in healthy participants to evaluate its safety and tolerability, but it has not yet received regulatory approval for any use.