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LY4167586

Phase 1

Overweight | Small molecule | Metabolic |Eli Lilly and Company|Last Updated: Jul 29, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment84

FDA Designations

No designations recorded

Clinical trial landscape

LY4167586 · 1 trial · 2 indications

Phase 1 1
NCT07225556A Study of LY4167586 in Participants With Obesity or Overweight Who Are Otherwise HealthyOverweight
ACTIVE NOT_RECRUITING84 Analytics
PHASE1ACTIVE NOT_RECRUITING
A Study of LY4167586 in Participants With Obesity or Overweight Who Are Otherwise Healthy
OverweightUnlock trial analytics

Study Endpoints

Primary Endpoints

Number and Incidence of Serious Adverse Events (SAEs)
Baseline to study completion (up to 29 weeks)

A summary of SAEs regardless of causality, will be reported in the Reported Adverse Events module

Secondary Endpoints

Pharmacokinetics (PK): Maximum Observed Drug Concentration (Cmax)
Predose on Day 1 through end of the Follow-up Period (Week 25)
PK: Time of Maximum Drug Concentration (tmax)
Predose on Day 1 through end of the Follow-up Period (Week 25)
PK: Area Under the Concentration Versus Time Curve (AUC)
Predose on Day 1 through end of the Follow-up Period (Week 25)
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY4167586 (Cohorts A1 to A6)EXPERIMENTALLY4167586 administered subcutaneously (SC)
Placebo (Cohorts A1 to A6)PLACEBO_COMPARATORPlacebo administered SC
LY4167586 (Cohort B)EXPERIMENTALLY4167586 administered intravenously (IV)

Interventions

NameTypeDescription
LY4167586DRUGAdministered SC
PlaceboDRUGAdministered SC
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Participant must be 21 for Singapore site * Have a body mass index (BMI) between 27.0 kilogram per square meter (kg/m²) and 35.0 kg/m², inclusive * Have had a self-reported stable weight for 3 months prior to screening (less than approximately 5 percent \[%\] body weight chang...

Countries:United StatesSingapore
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Recent Changes (Last 90 Days)

LOWJul 29, 2026NCT07225556lastUpdatePostDate: changed
LOWJul 29, 2026NCT07225556lastUpdatePostDate: changed
MEDIUMJul 17, 2026NCT07225556Status: RECRUITING → ACTIVE_NOT_RECRUITING
MEDIUMJul 17, 2026NCT07225556Status: RECRUITING → ACTIVE_NOT_RECRUITING
MEDIUMJul 17, 2026NCT07225556Status: RECRUITING → ACTIVE_NOT_RECRUITING

Frequently asked questions about LY4167586

What is LY4167586 used for?

LY4167586 is an investigational small molecule being developed for the treatment of overweight and obesity. It is currently in Phase 1 clinical development, studied in participants with obesity or overweight who are otherwise healthy.

Who makes LY4167586?

LY4167586 is being developed by Eli Lilly and Company, a pharmaceutical company listed on the stock exchange under the ticker symbol LLY.

What phase is LY4167586 in?

LY4167586 is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. A Phase 1 study is currently active but not recruiting participants.

What clinical trials is LY4167586 in?

LY4167586 is being studied in a Phase 1 clinical trial with the identifier NCT07225556. This trial is titled 'A Study of LY4167586 in Participants With Obesity or Overweight Who Are Otherwise Healthy' and is being conducted in the United States and Singapore.

Is LY4167586 being studied in a randomized controlled trial?

Yes, the Phase 1 clinical trial of LY4167586 is randomized, double-blind, and placebo-controlled. The study enrolls 84 participants, including healthy volunteers, and is designed to evaluate the drug in individuals with overweight or obesity.