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LY4060874

Phase 1

Healthy Participants | Small molecule | Other |Eli Lilly and Company|Last Updated: Apr 3, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment121

FDA Designations

No designations recorded

Clinical trial landscape

LY4060874 · 1 trial · 1 indication

Phase 1 1
NCT06709820A Study of LY4060874 in Healthy ParticipantsHealthy Participants
COMPLETED121 Analytics
PHASE1COMPLETED
A Study of LY4060874 in Healthy Participants
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Study Endpoints

Primary Endpoints

Number of Participants With One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs)
Baseline up to 22 Weeks

Number of participants with one or more TEAEs and SAEs.

Secondary Endpoints

Pharmacokinetics (PK): Area Under the Concentration Versus Time (AUC) of LY4060874
PK: Part A: Baseline up to 13 weeks; Part B and C: Baseline up to 18 weeks
PK: Maximum Observed Concentration of LY4060874
PK: Part A: Baseline up to 13 weeks; Part B and C: Baseline up to 18 weeks
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY4060874 (Part A Subcutaneous)EXPERIMENTALSingle ascending dose of LY4060874 administered subcutaneously (SC).
LY4060874 (Part A Intravenous)EXPERIMENTALSingle ascending dose of LY4060874 administered intravenously (IV).
LY4060874 (Part B)EXPERIMENTALMultiple ascending doses of LY4060874 administered SC.
LY4060874 (Part B Chinese)EXPERIMENTALMultiple ascending doses of LY4060874 administered SC in Chinese participants.
LY4060874 (Part C Japanese)EXPERIMENTALMultiple ascending doses of LY4060874 administered SC in Japanese participants.
Placebo (SC)PLACEBO_COMPARATORPlacebo administered SC in Part A, B, and C.
Placebo (IV)PLACEBO_COMPARATORPlacebo administered IV in Part A.

Interventions

NameTypeDescription
LY4060874DRUGAdministered SC
PlaceboDRUGAdministered SC
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Are overtly healthy as determined by medical evaluation, including medical history and physical examination. * Have a body mass index in the range of 20 to 29.9 kilogram per meter squared (kg/m²), inclusive, at screening. * To qualify as Chinese for this study, all 4 of the pa...

Countries:United StatesSingapore
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Frequently asked questions about LY4060874

What is LY4060874 used for?

LY4060874 is an investigational small molecule being studied in healthy participants. It is being evaluated in a Phase 1 clinical trial to assess its safety, tolerability, and pharmacokinetics. The drug is not approved for any medical condition and is currently in early-stage clinical development.

Who makes LY4060874?

LY4060874 is being developed by Eli Lilly and Company, a pharmaceutical company traded on the NYSE under the ticker symbol LLY. The company is conducting clinical research on this investigational small molecule in healthy participants.

What phase is LY4060874 in?

LY4060874 is in Phase 1 clinical development. The Phase 1 trial has been completed, and the drug remains investigational. It has not been approved by regulatory authorities and is still undergoing early-stage clinical evaluation.

What clinical trials is LY4060874 in?

LY4060874 has one completed Phase 1 clinical trial, identified as NCT06709820, titled "A Study of LY4060874 in Healthy Participants." This randomized, double-blind, placebo-controlled study enrolled 121 participants in the United States and Singapore.

Is LY4060874 FDA approved?

LY4060874 is not FDA approved. It is an investigational drug that has completed a Phase 1 clinical trial in healthy participants. The drug is still in clinical development and has not been authorized for use in any medical condition.