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LY4005130

Phase 2

Vitiligo | Small molecule | Immunology |Eli Lilly and Company|Last Updated: Jun 4, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment60
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07533019A Study of LY4005130 in Adult Participants With Non-Segmental VitiligoPHASE2 RECRUITING 60Apr 14, 2026Sep 1, 2027Jun 4, 202635 United States, Belgium +3
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Study Endpoints
Primary Endpoints
Percentage of Participants Achieving Facial Vitiligo Area Scoring Index (F-VASI) 75
Week 24
Secondary Endpoints
Percentage of Participants Achieving Total Vitiligo Area Scoring Index (T-VASI) 75
Week 24
Pharmacodynamics (PD): Change from Baseline in Gene Expression of Select Genes from Skin Biopsy
Baseline, Week 24
Pharmacokinetics (PK): Observed Trough of LY4005130 Serum Concentration
Week 24
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
LY4005130EXPERIMENTALLY4005130 administered intravenously (IV)
PlaceboPLACEBO_COMPARATORPlacebo administered IV
Interventions
NameTypeDescription
LY4005130DRUGAdministered IV
PlaceboDRUGAdministered IV
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Eligibility Criteria
Age Range18 Years — 75 Years
SexALL
Healthy VolunteersNo
Study Sites35

Inclusion Criteria: * Eligible participants must have the following at both screening and baseline: * A clinical diagnosis of non-segmented vitiligo (NSV) for at least 3 months * Body surface area (BSA) involvement of 4% to 60%, inclusive, excluding involvement at palms of the hands, soles of ...

Countries:United StatesBelgiumCanadaChinaPoland
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Recent Changes (Last 90 Days)
LOWJun 4, 2026NCT07533019lastUpdatePostDate: changed
LOWJun 4, 2026NCT07533019lastUpdatePostDate: changed
LOWJun 4, 2026NCT07533019lastUpdatePostDate: changed
LOWJun 4, 2026NCT07533019lastUpdatePostDate: changed
LOWMay 26, 2026NCT07533019lastUpdatePostDate: changed
LOWMay 24, 2026NCT07533019studyFirstPostDate: changed
LOWMay 21, 2026NCT07533019NEW_TRIAL: changed
LOWMay 21, 2026NCT07533019NEW_TRIAL: changed