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LY3985863

Phase 1

Healthy | Small molecule | Other |Eli Lilly and Company|Last Updated: Mar 11, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment24
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07030127A Study of LY3985863 in Healthy ParticipantsPHASE1 COMPLETED 24 — — Aug 11, 2025Feb 24, 2026Mar 11, 20261 China
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Study Endpoints
Primary Endpoints
Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline to Study Completion (Up to 19 Weeks)

A summary of TEAEs and SAEs regardless of causality, will be reported in the Reported Adverse Events module

Secondary Endpoints
Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY3985863
Predose on Day 1 up to Approximately Week 8 Post Dose
PK: Area Under the Concentration Versus Time Curve (AUC) of LY3985863
Predose on Day 1 up to Approximately Week 8 Post Dose
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE
Treatment Arms
ArmTypeDescription
LY3985863EXPERIMENTALAdministered subcutaneously (SC)
PlaceboPLACEBO_COMPARATORAdministered SC
Interventions
NameTypeDescription
LY3985863DRUGAdministered SC
PlaceboDRUGAdministered SC
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Are native Chinese participants * Are overtly healthy * Have body weight of at least 50.0 kilogram (kg) for male or 45.0 kg for female and a body mass index of 20.0 to 30.0 kilogram per square meter (kg/m²), inclusive * Have a stable body weight within 3 months Exclusion Crit...

Countries:China
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Recent Changes (Last 90 Days)
MEDIUMMay 21, 2026NCT07030127TRIAL_REMOVED: changed
MEDIUMMay 21, 2026NCT07030127TRIAL_REMOVED: changed