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LY3985863

Phase 1

Healthy | Small molecule | Other |Eli Lilly and Company|Last Updated: Mar 11, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment24

FDA Designations

No designations recorded

Clinical trial landscape

LY3985863 · 1 trial · 1 indication

Phase 1 1
NCT07030127A Study of LY3985863 in Healthy ParticipantsHealthy
COMPLETED24 Analytics
PHASE1COMPLETED
A Study of LY3985863 in Healthy Participants
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Study Endpoints

Primary Endpoints

Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline to Study Completion (Up to 19 Weeks)

A summary of TEAEs and SAEs regardless of causality, will be reported in the Reported Adverse Events module

Secondary Endpoints

Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY3985863
Predose on Day 1 up to Approximately Week 8 Post Dose
PK: Area Under the Concentration Versus Time Curve (AUC) of LY3985863
Predose on Day 1 up to Approximately Week 8 Post Dose
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY3985863EXPERIMENTALAdministered subcutaneously (SC)
PlaceboPLACEBO_COMPARATORAdministered SC

Interventions

NameTypeDescription
LY3985863DRUGAdministered SC
PlaceboDRUGAdministered SC
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Are native Chinese participants * Are overtly healthy * Have body weight of at least 50.0 kilogram (kg) for male or 45.0 kg for female and a body mass index of 20.0 to 30.0 kilogram per square meter (kg/m²), inclusive * Have a stable body weight within 3 months Exclusion Crit...

Countries:China
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Frequently asked questions about LY3985863

What is LY3985863?

LY3985863 is an investigational small molecule being developed by Eli Lilly and Company. It is currently in Phase 1 clinical development, studied in healthy participants. A completed trial evaluated its safety and tolerability in 24 healthy volunteers in China.

What is LY3985863 used for?

LY3985863 is being studied for use in healthy participants, meaning it is not yet indicated for any specific disease. Its Phase 1 trial, NCT07030127, was designed to assess the drug in healthy volunteers, a common early step in clinical development.

Who makes LY3985863?

LY3985863 is developed by Eli Lilly and Company, a pharmaceutical company traded on the NYSE under the ticker LLY. The company is conducting clinical trials to evaluate this investigational small molecule.

What phase is LY3985863 in?

LY3985863 is in Phase 1 clinical development. A Phase 1 trial, NCT07030127, has been completed, involving 24 healthy participants. The drug is investigational and has not been approved by regulatory authorities.

What clinical trials is LY3985863 in?

LY3985863 has one clinical trial, NCT07030127, titled "A Study of LY3985863 in Healthy Participants." This Phase 1, randomized, double-blind, placebo-controlled trial was completed in China, enrolling 24 healthy adults aged 18 years and older.

Is LY3985863 FDA approved?

LY3985863 is not FDA approved. It is an investigational drug in Phase 1 clinical development. The completed trial, NCT07030127, was conducted in healthy participants to evaluate the drug's safety and tolerability, but it has not been approved for any medical use.