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LY3876602

Phase 1

Healthy | Small molecule | Other |Eli Lilly and Company|Last Updated: Sep 24, 2025

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment74

FDA Designations

No designations recorded

Clinical trial landscape

LY3876602 · 1 trial · 1 indication

Phase 1 1
NCT06007638A Single and Multiple Ascending Dose Study of LY3876602 in Healthy ParticipantsHealthy
COMPLETED74 Analytics
PHASE1COMPLETED
A Single and Multiple Ascending Dose Study of LY3876602 in Healthy Participants
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Study Endpoints

Primary Endpoints

Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline up to 28 weeks

A summary of SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module

Secondary Endpoints

Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of LY3876602
Predose up to 28 weeks
PK: Maximum Observed Drug Concentration (Cmax) of LY3876602
Predose up to 28 weeks
PK: Half-life (t1/2) of LY3876602
Predose up to 28 weeks
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY3876602EXPERIMENTALSingle ascending doses of LY3876602 administered intravenously (IV).
PlaceboPLACEBO_COMPARATORPlacebo administered IV.
LY3876602 Part B (MAD)EXPERIMENTALMultiple ascending doses of LY3876602 will be administered intravenously (IV).
Placebo: Part B (MAD)PLACEBO_COMPARATORPlacebo administered IV

Interventions

NameTypeDescription
LY3876602DRUGAdministered IV.
PlaceboDRUGAdministered IV.
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Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Male and female participants who are overtly healthy as determined by medical evaluation * Have a body mass index with the range of 18 and less than or equal to (≤) 32 kilograms per square meter (kg/m²) * Male or female participants of nonchildbearing potential Exclusion Crit...

Countries:Netherlands
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Frequently asked questions about LY3876602

What is LY3876602?

LY3876602 is an investigational small molecule being developed by Eli Lilly and Company. It is currently in Phase 1 clinical development. The drug has been studied in healthy participants, and its specific therapeutic indication has not been established. It is not yet approved by regulatory authorities.

Who makes LY3876602?

LY3876602 is being developed by Eli Lilly and Company, a pharmaceutical company listed on the New York Stock Exchange under the ticker symbol LLY. The company is conducting clinical trials to evaluate the safety and tolerability of this investigational small molecule in healthy participants.

What phase is LY3876602 in?

LY3876602 is in Phase 1 clinical development. A Phase 1 study has been completed, which was designed to evaluate the safety, tolerability, and pharmacokinetics of the drug in healthy participants. The drug remains investigational and has not been approved for any medical use.

What clinical trials is LY3876602 in?

LY3876602 has been studied in one clinical trial, identified as NCT06007638. This was a Phase 1, single and multiple ascending dose study conducted in healthy participants in the Netherlands. The trial enrolled 74 participants and has been completed.

Is LY3876602 FDA approved?

LY3876602 is not FDA approved. It is an investigational drug currently in Phase 1 clinical development. The completed trial was a Phase 1 study in healthy participants, and the drug has not yet demonstrated efficacy or received regulatory approval for any indication.