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LY3876602

Phase 1

Undisclosed | Small molecule | Other |Eli Lilly and Company|Trials Updated: Sep 24, 2025

LY3876602 development status

Highest phase Phase 1
Registered trials 1 across 1 sponsor since Aug 2023

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment74

FDA Designations

No designations recorded

LY3876602 clinical trials

LY3876602 · 1 trial · 1 indication

Phase 1 1
NCT06007638A Single and Multiple Ascending Dose Study of LY3876602 in Healthy ParticipantsHealthy
COMPLETED74 Analytics
PHASE1COMPLETED
A Single and Multiple Ascending Dose Study of LY3876602 in Healthy Participants
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline up to 28 weeks

A summary of SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module

Secondary Endpoints

Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of LY3876602
Predose up to 28 weeks
PK: Maximum Observed Drug Concentration (Cmax) of LY3876602
Predose up to 28 weeks
PK: Half-life (t1/2) of LY3876602
Predose up to 28 weeks
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY3876602EXPERIMENTALSingle ascending doses of LY3876602 administered intravenously (IV).
PlaceboPLACEBO_COMPARATORPlacebo administered IV.
LY3876602 Part B (MAD)EXPERIMENTALMultiple ascending doses of LY3876602 will be administered intravenously (IV).
Placebo: Part B (MAD)PLACEBO_COMPARATORPlacebo administered IV

Interventions

NameTypeDescription
LY3876602DRUGAdministered IV.
PlaceboDRUGAdministered IV.
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Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Male and female participants who are overtly healthy as determined by medical evaluation * Have a body mass index with the range of 18 and less than or equal to (≤) 32 kilograms per square meter (kg/m²) * Male or female participants of nonchildbearing potential Exclusion Crit...

Countries:Netherlands
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Frequently asked questions about LY3876602

What is LY3876602?

LY3876602 is an investigational small molecule being developed by Eli Lilly and Company. It has been studied in a Phase 1 clinical trial in healthy adult participants. The specific disease or condition it is intended to treat has not been disclosed.

Who is developing LY3876602?

LY3876602 is being developed by Eli Lilly and Company, which trades on the New York Stock Exchange under the ticker LLY. Lilly conducted the Phase 1 study of the compound in healthy volunteers.

What phase is LY3876602 in?

LY3876602 is in Phase 1 clinical development. Its single Phase 1 trial, a single and multiple ascending dose study in healthy participants, has been completed. The drug remains investigational and has not been approved by the FDA.

What clinical trials is LY3876602 in?

LY3876602 has been evaluated in one clinical trial, NCT06007638, titled A Single and Multiple Ascending Dose Study of LY3876602 in Healthy Participants. The Phase 1 trial enrolled 74 healthy adults in the Netherlands and is completed.

How was the LY3876602 Phase 1 trial designed?

The Phase 1 trial NCT06007638 was a randomized, double-blind, placebo-controlled study of single and multiple ascending doses of LY3876602. It enrolled 74 healthy participants aged 18 years and older in the Netherlands and has been completed.