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LY3876602

Phase 1

Healthy | Small molecule | Other |Eli Lilly and Company|Last Updated: Sep 24, 2025

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment74
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06007638A Single and Multiple Ascending Dose Study of LY3876602 in Healthy ParticipantsPHASE1 COMPLETED 74Aug 23, 2023Sep 20, 2025Sep 24, 20251 Netherlands
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Study Endpoints
Primary Endpoints
Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline up to 28 weeks

A summary of SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module

Secondary Endpoints
Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of LY3876602
Predose up to 28 weeks
PK: Maximum Observed Drug Concentration (Cmax) of LY3876602
Predose up to 28 weeks
PK: Half-life (t1/2) of LY3876602
Predose up to 28 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE
Treatment Arms
ArmTypeDescription
LY3876602EXPERIMENTALSingle ascending doses of LY3876602 administered intravenously (IV).
PlaceboPLACEBO_COMPARATORPlacebo administered IV.
LY3876602 Part B (MAD)EXPERIMENTALMultiple ascending doses of LY3876602 will be administered intravenously (IV).
Placebo: Part B (MAD)PLACEBO_COMPARATORPlacebo administered IV
Interventions
NameTypeDescription
LY3876602DRUGAdministered IV.
PlaceboDRUGAdministered IV.
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Eligibility Criteria
Age Range18 Years — 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Male and female participants who are overtly healthy as determined by medical evaluation * Have a body mass index with the range of 18 and less than or equal to (≤) 32 kilograms per square meter (kg/m²) * Male or female participants of nonchildbearing potential Exclusion Crit...

Countries:Netherlands
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