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LY3873862

Phase 1

Healthy | Small molecule | Other |Eli Lilly and Company|Last Updated: May 11, 2025

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment84

FDA Designations

No designations recorded

Clinical trial landscape

LY3873862 · 1 trial · 1 indication

Phase 1 1
NCT05492201A Study of LY3873862 in Healthy ParticipantsHealthy
COMPLETED84 Analytics
PHASE1COMPLETED
A Study of LY3873862 in Healthy Participants
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Study Endpoints

Primary Endpoints

Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline through 72 days

A summary of TEAEs, SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module

Secondary Endpoints

Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve From Zero to Infinity (AUC[0-∞]) of LY3873862
Predose up to 96 hours postdose
PK: Area Under the Concentration versus Time Curve at Steady State (AUCτ) of LY3873862
Predose up to 96 hours postdose
PK: Maximum Observed Concentration (Cmax) of LY3873862
Predose up to 96 hours postdose
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY3873862 (Part A)EXPERIMENTALLY3873862 administered orally as single dose.
Placebo (Part A)PLACEBO_COMPARATORPlacebo administered orally.
LY3873862 (Part B)EXPERIMENTALLY3873862 administered orally as multiple doses.
Placebo (Part B)PLACEBO_COMPARATORPlacebo administered orally.
LY3873862 (Part C)EXPERIMENTALLY3873862 administered orally as multiple doses.
Placebo (Part C)PLACEBO_COMPARATORPlacebo administered orally.

Interventions

NameTypeDescription
LY3873862DRUGAdministered orally.
PlaceboDRUGAdministered orally.
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Participants who are overtly healthy as determined by medical evaluation * Body mass index (BMI) within the range 18.0 to 32.0 kilograms per meter squared (kg/m²) * Are male or female participants, including those of childbearing potential Exclusion Criteria: * Have a histor...

Countries:United Kingdom
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Frequently asked questions about LY3873862

What is LY3873862?

LY3873862 is an investigational small molecule being developed by Eli Lilly and Company. It is currently in Phase 1 clinical development, studied in healthy participants. The drug is not approved and remains under investigation.

What is LY3873862 used for?

LY3873862 is being studied in healthy participants as part of early clinical development. Its intended therapeutic use has not been established, as it is still in Phase 1 trials.

Who makes LY3873862?

LY3873862 is developed by Eli Lilly and Company, a biopharmaceutical company traded on the NYSE under the ticker LLY.

What phase is LY3873862 in?

LY3873862 is in Phase 1 clinical development. A Phase 1 study in healthy participants has been completed, and the drug remains investigational.

What clinical trials is LY3873862 in?

LY3873862 has one completed Phase 1 trial, NCT05492201, titled "A Study of LY3873862 in Healthy Participants." The trial enrolled 84 healthy participants in the United Kingdom and was placebo-controlled and double-blind.

Is LY3873862 FDA approved?

LY3873862 is not FDA approved. It is an investigational drug currently in Phase 1 clinical development, with a completed study in healthy participants.