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LY3873862

Phase 1

Undisclosed | Small molecule | Other |Eli Lilly and Company|Trials Updated: May 11, 2025

LY3873862 development status

Highest phase Phase 1
Registered trials 1 across 1 sponsor since Aug 2022

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment84

FDA Designations

No designations recorded

LY3873862 clinical trials

LY3873862 · 1 trial · 1 indication

Phase 1 1
NCT05492201A Study of LY3873862 in Healthy ParticipantsHealthy
COMPLETED84 Analytics
PHASE1COMPLETED
A Study of LY3873862 in Healthy Participants
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline through 72 days

A summary of TEAEs, SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module

Secondary Endpoints

Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve From Zero to Infinity (AUC[0-∞]) of LY3873862
Predose up to 96 hours postdose
PK: Area Under the Concentration versus Time Curve at Steady State (AUCτ) of LY3873862
Predose up to 96 hours postdose
PK: Maximum Observed Concentration (Cmax) of LY3873862
Predose up to 96 hours postdose
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY3873862 (Part A)EXPERIMENTALLY3873862 administered orally as single dose.
Placebo (Part A)PLACEBO_COMPARATORPlacebo administered orally.
LY3873862 (Part B)EXPERIMENTALLY3873862 administered orally as multiple doses.
Placebo (Part B)PLACEBO_COMPARATORPlacebo administered orally.
LY3873862 (Part C)EXPERIMENTALLY3873862 administered orally as multiple doses.
Placebo (Part C)PLACEBO_COMPARATORPlacebo administered orally.

Interventions

NameTypeDescription
LY3873862DRUGAdministered orally.
PlaceboDRUGAdministered orally.
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Participants who are overtly healthy as determined by medical evaluation * Body mass index (BMI) within the range 18.0 to 32.0 kilograms per meter squared (kg/m²) * Are male or female participants, including those of childbearing potential Exclusion Criteria: * Have a histor...

Countries:United Kingdom
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Frequently asked questions about LY3873862

What is LY3873862?

LY3873862 is an investigational small molecule being developed by Eli Lilly and Company. It has been studied in a Phase 1 clinical trial in healthy adult participants. The specific therapeutic indication for LY3873862 has not been disclosed.

Who is developing LY3873862?

LY3873862 is being developed by Eli Lilly and Company, which trades on the New York Stock Exchange under the ticker LLY. Lilly is the sponsor of the clinical program evaluating this small molecule.

What phase is LY3873862 in?

LY3873862 is in Phase 1 clinical development. One Phase 1 trial has been completed. The drug is investigational and has not been approved by the FDA for any indication.

What clinical trials is LY3873862 in?

LY3873862 has been evaluated in one Phase 1 trial, NCT05492201, titled A Study of LY3873862 in Healthy Participants. The trial enrolled 84 healthy volunteers in the United Kingdom, was randomized, double-blind, and placebo-controlled, and is now completed.

What is LY3873862 used for?

LY3873862 has no disclosed therapeutic indication. Its only reported clinical study was conducted in healthy participants rather than in patients with a specific disease, so no approved or investigational use has been announced.