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LY3867070

Phase 1

Healthy | Small molecule | Other |Eli Lilly and Company|Last Updated: Jun 3, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment196

FDA Designations

No designations recorded

Clinical trial landscape

LY3867070 · 1 trial · 1 indication

Phase 1 1
NCT07021547A Study of LY3867070 in Healthy ParticipantsHealthy
RECRUITING196 Analytics
PHASE1RECRUITING
A Study of LY3867070 in Healthy Participants
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Study Endpoints

Primary Endpoints

Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline up to Approximately Week 7

A summary of TEAEs regardless of causality, will be reported in the Reported Adverse Events module

Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline up to Approximately Week 7

A summary of SAEs regardless of causality, will be reported in the Reported Adverse Events module

Number of Participants with One or More Adverse Event(s) (AEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline up to Approximately Week 7

A summary of AEs regardless of causality, will be reported in the Reported Adverse Events module

Secondary Endpoints

Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of LY3867070
Baseline up to Approximately Week 7
PK: Maximum Concentration (Cmax) of LY3867070
Baseline up to Approximately Week 7
Part B Pharmacodynamic (PD): Change from Baseline in Gene Expression
Baseline up to Approximately Week 6
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY3867070 (Part A)EXPERIMENTALSingle-Ascending Dose of LY3867070 administered orally
LY3867070 (Part B)EXPERIMENTALMultiple-Ascending Doses of LY3867070 administered orally
LY3867070 (Part C)EXPERIMENTALMultiple Doses of LY3867070 administered orally
Placebo (Parts A-C)PLACEBO_COMPARATORPlacebo administered orally
LY3867070 (Part D)EXPERIMENTALDrug-Drug Interaction (DDI) administered orally

Interventions

NameTypeDescription
LY3867070DRUGAdministered orally
PlaceboDRUGAdministered orally
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Are overtly healthy as determined by medical evaluation * Part C of the study includes only Japanese and Chinese participants * Have a body weight greater than or equal to 45 kilogram (kg) and also body mass index 18 to 32 kilogram per square meter (kg/m²) inclusive Exclusion...

Countries:United States
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Frequently asked questions about LY3867070

What is LY3867070 used for?

LY3867070 is an investigational small molecule being studied in healthy participants. It is currently in Phase 1 clinical development, and the ongoing trial is evaluating its safety and tolerability in healthy volunteers. It is not approved for any medical condition.

Who makes LY3867070?

LY3867070 is being developed by Eli Lilly and Company, a biopharmaceutical company traded on the NYSE under the ticker symbol LLY. The company is conducting a Phase 1 clinical trial of LY3867070 in healthy participants in the United States.

What phase is LY3867070 in?

LY3867070 is in Phase 1 clinical development. The drug is investigational and has not been approved by regulatory authorities. It is currently being studied in a single Phase 1 trial that is recruiting healthy participants.

What clinical trials is LY3867070 in?

LY3867070 is being evaluated in one Phase 1 clinical trial, identified as NCT07021547, titled "A Study of LY3867070 in Healthy Participants." The trial is recruiting 196 healthy participants in the United States and is a randomized, double-blind, placebo-controlled study.

Is LY3867070 FDA approved?

LY3867070 is not FDA approved. It is an investigational drug currently in Phase 1 clinical trials. The ongoing study is designed to assess the safety and tolerability of LY3867070 in healthy participants, and it has not yet been evaluated for efficacy in any patient population.