Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT03023826 | A Study of LY3202626 in Healthy Participants | PHASE1 | COMPLETED | 26 | — | — | Jan 15, 2017 | Apr 4, 2017 | Apr 19, 2021 | 1 | Singapore |
| NCT02555449 | A Study of [¹⁴C]-LY3202626 in Healthy Male Participants | PHASE1 | COMPLETED | 6 | — | — | Sep 1, 2015 | Nov 1, 2015 | Apr 19, 2021 | 1 | United States |
Pharmacokinetics (PK) is the maximum observed drug concentration (Cmax) of LY3202626
PK is the area under the concentration versus time curve from time zero to infinity (AUC\[0-∞\]) of LY3202626
PK is the AUC from time zero to time t, where t is the last time point with a measurable concentration (AUC\[0-tlast\]) of LY3202626
Fecal excretion of radioactivity over time expressed as a percentage of the total radioactive dose administered.
Urinary excretion of radioactivity over time was expressed as a percentage of the total radioactive dose administered
| Arm | Type | Description |
|---|---|---|
| LY3202626 (R-Fasting) | EXPERIMENTAL | Single oral dose of LY3202626 (R) capsule under fasting conditions. |
| LY3202626 (T1-Fasting) | EXPERIMENTAL | Single oral dose of LY3202626 (T1) tablet under fasting conditions. |
| LY3202626 (T1-Fed) | EXPERIMENTAL | Single oral dose of LY3202626 (T1) following a high fat breakfast. |
| [¹⁴C]-LY3202626 | EXPERIMENTAL | Single oral dose of LY3202626 containing 100 micro curies of radioactivity |
| Name | Type | Description |
|---|---|---|
| LY3202626 (R-Fasting) | DRUG | Administered orally |
| LY3202626 (T1-Fasting) | DRUG | Administered orally |
| LY3202626 (T1-Fed) | DRUG | Administered orally |
| [¹⁴C]-LY3202626 | DRUG | Administered as solution by mouth |
Inclusion Criteria: * Are overtly healthy males or females, as determined by medical history and physical examination * Female participants must be of non-childbearing potential confirmed by medical history or menopause * Have a body mass index (BMI) of 18.5 to 32.0 kilograms per meter squared (kg/...