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LY3200327

Phase 1

Undisclosed | Small molecule | Other |Eli Lilly and Company|Trials Updated: Sep 12, 2016

LY3200327 target and mechanism

ModalitySmall molecule

Also known as LY3200327 (SC)

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment52

FDA Designations

No designations recorded

LY3200327 clinical trials

LY3200327 · 1 trial · 1 indication

Phase 1 1
NCT02595736A Study of LY3200327 in Healthy ParticipantsHealthy
COMPLETED52 Analytics
PHASE1COMPLETED
A Study of LY3200327 in Healthy Participants
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Study Endpoints

Primary Endpoints

Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline to study completion (approximately 12 weeks)

Secondary Endpoints

Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY3200327
Pre-dose up to 84 days post dose
Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of LY3200327
Pre-dose up to 84 days post dose
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
Placebo (SC)PLACEBO_COMPARATORSingle subcutaneous (SC) dose of placebo
LY3200327 (SC)EXPERIMENTALSingle escalating subcutaneous (SC) dose of LY3200327
LY3200327 (IV)EXPERIMENTALSingle intravenous (IV) dose of LY3200327
Placebo (IV)PLACEBO_COMPARATORSingle intravenous (IV) dose of placebo

Interventions

NameTypeDescription
Placebo (SC)DRUGAdministered SC
LY3200327 (SC)DRUGAdministered SC
LY3200327 (IV)DRUGAdministered IV
Placebo (IV)DRUGAdministered IV
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * At the time of initial screening, in general good health * First-generation healthy Japanese (age 20 to 65 years) will be included Exclusion Criteria: * Pregnancy or breastfeeding during the study * Chronic infection * Treatment with prohibited medications

Countries:United States
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Frequently asked questions about LY3200327

What is LY3200327?

LY3200327 is an investigational small molecule developed by Eli Lilly and Company. It has been studied in a Phase 1 clinical trial in healthy participants. The specific therapeutic indication for LY3200327 has not been disclosed.

Who is developing LY3200327?

LY3200327 is being developed by Eli Lilly and Company, which trades on the New York Stock Exchange under the ticker symbol LLY.

What phase is LY3200327 in?

LY3200327 is in Phase 1 clinical development. It has not been approved by the FDA and remains investigational.

What clinical trials is LY3200327 in?

LY3200327 has been evaluated in one completed Phase 1 trial, NCT02595736, titled A Study of LY3200327 in Healthy Participants. The trial enrolled 52 healthy volunteers in the United States and was randomized, double-blind, and placebo-controlled.

Is LY3200327 the same as LY3200327 (SC)?

Yes, LY3200327 (SC) is an alternative name for LY3200327. Both refer to the same investigational small molecule developed by Eli Lilly and Company.