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LY3192767

Phase 1

Healthy | Small molecule | Other |Eli Lilly and Company|Last Updated: Apr 5, 2019

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment57

FDA Designations

No designations recorded

Clinical trial landscape

LY3192767 · 1 trial · 1 indication

Phase 1 1
NCT03025009A Study of LY3192767 in Healthy ParticipantsHealthy
COMPLETED57 Analytics
PHASE1COMPLETED
A Study of LY3192767 in Healthy Participants
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Study Endpoints

Primary Endpoints

Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline through Study Completion (up to about Day 49)

A summary of SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module

Secondary Endpoints

Pharmacokinetics (PK): Time to Maximum Concentration (Tmax) of LY3192767
Predose through 336 Hours
PK: Maximum Serum Concentration (Cmax) of LY3192767
Predose through 336 Hours
PK: Area Under the Concentration-Time Curve from Time Zero to Infinity (AUC[0-inf] of LY3192767
Predose through 336 Hours
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY3192767 (Part A)EXPERIMENTALEscalating doses of LY3192767 administered subcutaneously (SC).
Placebo (Part A)PLACEBO_COMPARATORPlacebo matching LY3192767 administered subcutaneously (SC).
LY3192767 (Part B)EXPERIMENTALLY3192767 administered as a SC injection in one of three study periods.
Basal Insulin Peglispro (Part B)ACTIVE_COMPARATORBasal insulin peglispro administered as a SC injection in one of three study periods.
Insulin Glargine (Part B)ACTIVE_COMPARATORInsulin glargine administered as a SC injection in one of three study periods.

Interventions

NameTypeDescription
LY3192767DRUGAdministered SC.
Basal Insulin PeglisproDRUGAdministered SC.
Insulin GlargineDRUGAdministered SC.
PlaceboDRUGAdministered SC.
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Eligibility Criteria

Age Range20 Years to 64 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Are overtly healthy males or females, as determined by medical history and physical examination * Have a body mass index (BMI) of \>18.5 and \<30.0 kilogram per square meter (kg/m²), inclusive Exclusion Criteria: * Are currently enrolled in a clinical trial involving an inve...

Countries:Germany
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Frequently asked questions about LY3192767

What is LY3192767?

LY3192767 is an investigational small molecule being developed by Eli Lilly and Company. It is currently in Phase 1 clinical development. The drug has been studied in healthy participants, and its therapeutic area is classified as Other. As of now, it is not approved and remains in clinical testing.

What is LY3192767 used for?

LY3192767 is being studied for use in healthy participants, meaning it is not intended for a specific disease indication at this stage. The Phase 1 trial was designed to evaluate the drug in healthy volunteers, which is a common early step in clinical development to assess safety and tolerability.

Who makes LY3192767?

LY3192767 is developed by Eli Lilly and Company, a pharmaceutical company traded on the stock exchange under the ticker symbol LLY. The company is conducting clinical trials to evaluate this investigational small molecule in healthy participants.

What phase is LY3192767 in?

LY3192767 is in Phase 1 clinical development. The drug is investigational and has not been approved. A Phase 1 trial in healthy participants has been completed, and the drug is still in the early stages of clinical testing.

What clinical trials is LY3192767 in?

LY3192767 has one completed Phase 1 clinical trial, identified as NCT03025009, titled "A Study of LY3192767 in Healthy Participants." This trial enrolled 57 healthy volunteers in Germany, with participants aged 20 years and older. The study was randomized, double-blind, and placebo-controlled.

Is LY3192767 FDA approved?

LY3192767 is not FDA approved. It is an investigational drug currently in Phase 1 clinical development. The drug has been studied in a completed Phase 1 trial in healthy participants, but it has not received approval from regulatory authorities.