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LY3090106

Phase 1

Healthy | Small molecule | Other |Eli Lilly and Company|Last Updated: May 3, 2019

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment30
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03736772A Study of LY3090106 in Japanese and Caucasian Healthy ParticipantsPHASE1 COMPLETED 30Nov 19, 2018Mar 13, 2019May 3, 20191 United States
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Study Endpoints
Primary Endpoints
Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline through Day 85

A summary of SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module

Secondary Endpoints
Maximum Observed Drug Concentration (Cmax) of LY3090106
Baseline through Day 85
Area Under the Concentration-Versus-Time Curve (AUC) of LY3090106
Baseline through Day 85
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE
Treatment Arms
ArmTypeDescription
LY3090106EXPERIMENTALLY3090106 administered subcutaneously (SC)
PlaceboPLACEBO_COMPARATORPlacebo administered SC
Interventions
NameTypeDescription
LY3090106DRUGAdministered SC
PlaceboDRUGAdministered SC
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Eligibility Criteria
Age Range20 Years — 64 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Overtly healthy Japanese or Caucasian * Body mass index (BMI) 18.0 - 32.0 kilograms per square meter (kg/m²) Exclusion Criteria: * Have participated, within the last 30 days, in a clinical study involving an investigational product (IP). If the previous IP has a long half-li...

Countries:United States
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