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LY293111

Phase 2

Carcinoma, Non-Small-Cell Lung | Small molecule | Oncology |Eli Lilly and Company|Last Updated: Dec 21, 2007

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment195

FDA Designations

No designations recorded

Clinical trial landscape

LY293111 · 2 trials · 2 indications

Phase 2 2
NCT00069875A Study With Gemcitabine, Cisplatin, and LY293111 in Non-Small Cell Lung CancerCarcinoma, Non-Small-Cell Lung
COMPLETED195 Analytics
NCT00055250A Study With LY293111, Gemcitabine and Placebo in Patients With Pancreatic CancerPancreatic Cancer
COMPLETED130 Analytics
PHASE2COMPLETED
A Study With Gemcitabine, Cisplatin, and LY293111 in Non-Small Cell Lung Cancer
Carcinoma, Non-Small-Cell LungUnlock trial analytics
PHASE2COMPLETED
A Study With LY293111, Gemcitabine and Placebo in Patients With Pancreatic Cancer
Pancreatic CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

To determine if progression-free survival in patients with Stage IIIB or IV NSCLC receiving gemcitabine and cisplatin can be improved by adding 200 or 600 mg BID of LY293111 as compared to placebo.
6-month survival

Secondary Endpoints

time-to-event efficacy (overall survival, duration of response, time-to-response, time-to-treatment failure)
tumor response rate
toxicity rates
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
GemcitabineDRUG -
LY293111DRUG -
cisplatinDRUG -
placeboDRUG -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites19

Inclusion Criteria: * Non-Small Cell Lung Cancer, Stage IIIB or IV that is not amenable to either surgery of curative intent or radiation therapy * Tumor that can be measured by x-ray or scan * Adequate organ function Exclusion Criteria: * Inability to swallow capsules * Documented brain metastas...

Countries:United StatesCanadaGermanyIsraelNetherlandsSpain
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Frequently asked questions about LY293111

What is LY293111 used for?

LY293111 is an investigational small molecule being studied for the treatment of pancreatic cancer and non-small-cell lung cancer. It was evaluated in Phase 2 clinical trials in combination with other agents for these oncology indications.

Who makes LY293111?

LY293111 is being developed by Eli Lilly and Company, a pharmaceutical company traded on the New York Stock Exchange under the ticker symbol LLY.

What phase is LY293111 in?

LY293111 is in Phase 2 clinical development. It has completed two Phase 2 trials, one in pancreatic cancer and one in non-small-cell lung cancer, and is not approved for any use.

What clinical trials is LY293111 in?

LY293111 has been studied in two completed Phase 2 trials: NCT00055250, which tested LY293111 with gemcitabine and placebo in patients with pancreatic cancer, and NCT00069875, which tested LY293111 with gemcitabine and cisplatin in non-small-cell lung cancer.

Is LY293111 the same as any other drug?

LY293111 is also known by the code name LY293111. No other alternative names have been disclosed for this investigational agent.