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LY2886721 in a

Phase 1

Healthy Volunteers | Small molecule | Other |Eli Lilly and Company|Last Updated: Jul 19, 2019

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment26

FDA Designations

No designations recorded

Clinical trial landscape

LY2886721 in a · 1 trial · 1 indication

Phase 1 1
NCT01775904A Study of Two Dosage Forms of LY2886721 in Healthy ParticipantsHealthy Volunteers
COMPLETED26 Analytics
PHASE1COMPLETED
A Study of Two Dosage Forms of LY2886721 in Healthy Participants
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Study Endpoints

Primary Endpoints

Pharmacokinetics (PK): Maximum Observed Drug Concentration (Cmax) of LY2886721
Baseline through 96 hours post-dose
Pharmacokinetics (PK): Time of Maximum Observed Drug Concentration (Tmax) of LY2886721
Baseline through 96 hours post-dose
Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve From Time Zero to Time Tlast (AUC[0-tlast]) of LY2886721
Baseline through 96 hours post-dose
Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve From Time Zero to Infinity (AUC[0-∞] of LY2886721
Baseline through 96 hours post-dose
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY2886721 Capsule (water, fasting)EXPERIMENTALReference formulation. A single oral dose of 70 milligrams (mg) LY2886721 in a capsule given with water and without a meal in one of four periods.
LY2886721 ODT (no water, fasting)EXPERIMENTALA single oral dose of 70 mg LY2886721 in an orally disintegrating tablet (ODT) given without water and without a meal in one of four periods.
LY2886721 ODT (water, fed)EXPERIMENTALA single oral dose of a 70 mg LY2886721 in an orally disintegrating tablet (ODT) given with water and after a high-fat breakfast in one of four periods.
LY2886721 ODT (water, fasting)EXPERIMENTALA single oral dose of 70 mg LY2886721 in an orally disintegrating tablet (ODT) given with water and without a meal in one of four periods.

Interventions

NameTypeDescription
LY2886721 in a CapsuleDRUGAdministered orally.
LY2886721 in an orally disintegrating tablet (ODT)DRUGAdministered orally.
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Have a body mass index (BMI) of 18.5 to 32.0 kilograms per square meter (kg/m\^2), inclusive, at screening * At least 4 participants who are greater than 55 years of age * Male participants: Agree to use a reliable method of birth control and not donate sperm during the study ...

Countries:United States
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Frequently asked questions about LY2886721 in a

What is LY2886721 used for?

LY2886721 is an investigational small molecule being studied in healthy volunteers. It is not approved for any disease and is in early clinical development. The completed Phase 1 trial evaluated the drug in healthy participants to assess its safety and tolerability.

Who makes LY2886721?

LY2886721 is being developed by Eli Lilly and Company, a pharmaceutical company traded on the NYSE under the ticker symbol LLY. The company sponsored the clinical trial of this investigational drug.

What phase is LY2886721 in?

LY2886721 is in Phase 1 clinical development. The single trial listed for this drug is a completed Phase 1 study. As an investigational drug, it has not been approved by regulatory authorities and remains in clinical testing.

What clinical trials is LY2886721 in?

LY2886721 has one completed clinical trial, identified as NCT01775904, titled "A Study of Two Dosage Forms of LY2886721 in Healthy Participants." This Phase 1 study enrolled 26 participants in the United States and evaluated the drug in healthy volunteers.

Is LY2886721 FDA approved?

LY2886721 is not FDA approved. It is an investigational drug that has completed a Phase 1 clinical trial in healthy volunteers. The drug is still in clinical development and has not been authorized for marketing or use in any disease.