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LY2775240

Phase 1

Healthy | Small molecule | Other |Eli Lilly and Company|Last Updated: Nov 7, 2017

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment35

FDA Designations

No designations recorded

Clinical trial landscape

LY2775240 · 1 trial · 1 indication

Phase 1 1
NCT02963779A Study of LY2775240 in Healthy ParticipantsHealthy
COMPLETED35 Analytics
PHASE1COMPLETED
A Study of LY2775240 in Healthy Participants
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Study Endpoints

Primary Endpoints

Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline through to final follow-up at approximately Week 14

Secondary Endpoints

Pharmacokinetics: Area Under the Concentration Curve (AUC) of LY2775240
Baseline through Day 5
Pharmacokinetics: Time to Maximal Blood Concentration of LY2775240
Baseline through Day 5
Pharmacokinetics: Maximum Concentration of LY2775240 in Blood
Baseline through Day 5
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelCROSSOVER
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY2775240 (Part A)EXPERIMENTALEscalating oral doses of LY2775240 administered in healthy participants
LY2775240 (Part B)EXPERIMENTALOral dose of LY2775240 in healthy participants
Placebo (Part A)PLACEBO_COMPARATORPlacebo administered orally in healthy participants
Apremilast (Part B)ACTIVE_COMPARATOROral dose of apremilast in healthy participants

Interventions

NameTypeDescription
LY2775240DRUGAdministered orally
PlaceboDRUGAdministered orally
ApremilastDRUGAdministered orally
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Eligibility Criteria

Age Range21 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Overtly healthy adult male or a female who cannot get pregnant * Have a screening body mass index (BMI) of greater than 18 and less than or equal to 32 kilograms per meter square (kg/m²), inclusive * Have normal blood pressure, pulse rate, electrocardiogram (ECG) and medical t...

Countries:Singapore
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Frequently asked questions about LY2775240

What is LY2775240?

LY2775240 is an investigational small molecule being developed by Eli Lilly and Company. It is currently in Phase 1 clinical development. The drug has been studied in healthy participants, and its therapeutic area is classified as Other. As of now, it is not approved and remains in clinical trials.

What is LY2775240 used for?

LY2775240 is being studied for use in healthy participants. It is an investigational small molecule in Phase 1 clinical development. The drug has not been approved for any medical condition, and its current trials focus on assessing its effects in healthy volunteers rather than treating a specific disease.

Who makes LY2775240?

LY2775240 is developed by Eli Lilly and Company, a pharmaceutical company traded on the stock exchange under the ticker symbol LLY. The drug is currently in Phase 1 clinical development and has been studied in healthy participants.

What phase is LY2775240 in?

LY2775240 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities. The drug has completed one Phase 1 trial in healthy participants, and no active trials are currently listed.

What clinical trials is LY2775240 in?

LY2775240 has been studied in one clinical trial, identified as NCT02963779, titled "A Study of LY2775240 in Healthy Participants." This Phase 1 trial was completed and enrolled 35 participants in Singapore. The trial was randomized, double-blind, and placebo-controlled, involving healthy volunteers aged 21 years and older.