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LY2393910

Phase 1

Diabetes Mellitus, Type 2 | Small molecule | Metabolic |Eli Lilly and Company|Last Updated: Jun 10, 2011

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment38

FDA Designations

No designations recorded

Clinical trial landscape

LY2393910 · 1 trial · 1 indication

Phase 1 1
NCT01253278A Multiple-Ascending Dose Study in Type 2 Diabetes Mellitus PatientsDiabetes Mellitus, Type 2
COMPLETED38 Analytics
PHASE1COMPLETED
A Multiple-Ascending Dose Study in Type 2 Diabetes Mellitus Patients
Diabetes Mellitus, Type 2Unlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with Clinically Significant Effects
Over four weeks

Secondary Endpoints

Pharmacokinetics of LY2393910, Area Under the Curve (AUC)
From predose Day 1 up until Day 19
Change from baseline to day 28 in glucagon
Baseline, day 28
Pharmacokinetics of LY2393910, maximum concentration (Cmax)
From predose Day 1 up until Day 19
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL

Treatment Arms

ArmTypeDescription
20 mg LY2393910EXPERIMENTAL -
60 mg LY2393910EXPERIMENTAL -
150 mg LY2393910EXPERIMENTAL -
450 mg LY2393910EXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -

Interventions

NameTypeDescription
LY2393910DRUGas capsules, administered orally once daily for two weeks
PlaceboDRUGas capsules, administered orally once daily for two weeks
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Eligibility Criteria

Age Range21 Years to 70 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Diagnosis of type 2 diabetes mellitus * Must be on a stable treatment regimen (maintained on diet/exercise therapy with or without metformin) for at least 4 weeks prior to study entry * Have a glycated haemoglobin (HbA1c) value greater than or equal to 6.5% and less than or eq...

Countries:Germany
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Frequently asked questions about LY2393910

What is LY2393910 used for?

LY2393910 is an investigational small molecule being developed for the treatment of Type 2 Diabetes Mellitus. It is currently in Phase 1 clinical development and has not been approved by regulatory authorities. The drug is being studied in patients with Type 2 diabetes to evaluate its safety, tolerability, and pharmacokinetics.

What does LY2393910 target?

The molecular target of LY2393910 has not been disclosed. The drug is a small molecule being investigated for its potential role in managing Type 2 Diabetes Mellitus, but its specific mechanism of action is not publicly available at this time.

Who makes LY2393910?

LY2393910 is being developed by Eli Lilly and Company, a pharmaceutical company listed on the New York Stock Exchange under the ticker symbol LLY. The company is conducting clinical research on this investigational drug for the treatment of Type 2 Diabetes Mellitus.

What phase is LY2393910 in?

LY2393910 is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA or any other regulatory agency. The drug is still in the early stages of clinical testing, with one Phase 1 trial completed to date.

What clinical trials is LY2393910 in?

LY2393910 has one completed clinical trial, identified as NCT01253278, titled "A Multiple-Ascending Dose Study in Type 2 Diabetes Mellitus Patients." This Phase 1 study enrolled 38 participants in Germany and was a randomized, double-blind, placebo-controlled trial. The trial has been completed, and no active trials are currently listed.