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ULTRAM

Phase 1

Pain | Small molecule | Pain |Johnson & Johnson|Last Updated: Aug 29, 2012

Success Probability

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Market & Valuation

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Trial Design

CONTROLLED
Total Trials2
Total Enrollment75

FDA Designations

No designations recorded

Clinical trial landscape

ULTRAM · 2 trials · 1 indication

Phase 1 2
NCT01586494A Pharmacokinetic, Tolerability, and Safety Study of ULTRAM ER in Children With PainPain
COMPLETED37 Analytics
NCT01586507A Study of ULTRAM ER at Two Dose Levels in Adolescents With PainPain
COMPLETED38 Analytics
PHASE1COMPLETED
A Pharmacokinetic, Tolerability, and Safety Study of ULTRAM ER in Children With Pain
PainUnlock trial analytics
PHASE1COMPLETED
A Study of ULTRAM ER at Two Dose Levels in Adolescents With Pain
PainUnlock trial analytics

Study Endpoints

Primary Endpoints

The area under the curve (AUC∞) of ULTRAM ER as the primary PK parameter
At 1, 4, 6, 8, 12, 16, 24, 36, and 48 hours post dose

Secondary Endpoints

Plasma concentration profile of ULTRAM ER
At 1, 4, 6, 8, 12, 16, 24, 36, and 48 hours post dose
Plasma concentration profiles of M1 and M5 metabolites
At 1, 4, 6, 8, 12, 16, 24, 36, and 48 hours post dose
Incidence of adverse events as a measure of safety and tolerability
48 hours post dose
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Group 1EXPERIMENTAL -
Group 2EXPERIMENTAL -

Interventions

NameTypeDescription
ULTRAM ERDRUGOne dose of ULTRAM ER that is closest to 2 mg/kg, based on the participant's body weight and adjusting the dose in 25 mg increments.
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Eligibility Criteria

Age Range7 Years to 11 Years
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Confirmed need for control of pain due to injury or nonmalignant disease that does not influence fluid shifts and general drug disposition * Weighs at least 20 kg * Female participants must be premenarchal and in the opinion of the investigator not sexually active * Able to sw...

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Frequently asked questions about ULTRAM

What is ULTRAM used for?

ULTRAM is a small molecule drug being developed for the treatment of pain. It is currently in Phase 1 clinical development as an investigational product and is not yet approved by the FDA.

Who makes ULTRAM?

ULTRAM is being developed by Johnson & Johnson, a company traded on the New York Stock Exchange under the ticker symbol JNJ.

What phase is ULTRAM in?

ULTRAM is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA. Two Phase 1 trials have been completed, with a total of 75 participants enrolled.

What clinical trials is ULTRAM in?

ULTRAM has completed two Phase 1 clinical trials. The first, NCT01586494, studied ULTRAM ER in children aged 7 years and older with pain. The second, NCT01586507, studied ULTRAM ER at two dose levels in adolescents aged 12 years and older with pain.

Is ULTRAM the same as ULTRAM ER?

ULTRAM ER is the extended-release formulation of ULTRAM. Both names refer to the same drug product, with ULTRAM ER being the specific formulation studied in the clinical trials for pain.