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ULTRAM

Phase 1

Pain | Small molecule | Pain |Johnson & Johnson|Last Updated: Aug 29, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
CONTROLLEDBiomarker
Total Trials2
Total Enrollment75
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01586494A Pharmacokinetic, Tolerability, and Safety Study of ULTRAM ER in Children With PainPHASE1 COMPLETED 37Oct 1, 2007Jun 1, 2009Aug 29, 2012 -
NCT01586507A Study of ULTRAM ER at Two Dose Levels in Adolescents With PainPHASE1 COMPLETED 38Oct 1, 2007Sep 1, 2008Aug 29, 2012 -
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Study Endpoints
Primary Endpoints
The area under the curve (AUC∞) of ULTRAM ER as the primary PK parameter
At 1, 4, 6, 8, 12, 16, 24, 36, and 48 hours post dose
Secondary Endpoints
Plasma concentration profile of ULTRAM ER
At 1, 4, 6, 8, 12, 16, 24, 36, and 48 hours post dose
Plasma concentration profiles of M1 and M5 metabolites
At 1, 4, 6, 8, 12, 16, 24, 36, and 48 hours post dose
Incidence of adverse events as a measure of safety and tolerability
48 hours post dose
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Group 1EXPERIMENTAL -
Group 2EXPERIMENTAL -
Interventions
NameTypeDescription
ULTRAM ERDRUGOne dose of ULTRAM ER that is closest to 2 mg/kg, based on the participant's body weight and adjusting the dose in 25 mg increments.
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Eligibility Criteria
Age Range7 Years — 11 Years
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Confirmed need for control of pain due to injury or nonmalignant disease that does not influence fluid shifts and general drug disposition * Weighs at least 20 kg * Female participants must be premenarchal and in the opinion of the investigator not sexually active * Able to sw...

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