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Also known as NRT
Nicotine replacement therapy · 1 trial · 1 indication
| Arm | Type | Description |
|---|---|---|
| 1 | ACTIVE_COMPARATOR | Standard NRT user direction |
| 2 | EXPERIMENTAL | Novel NRT user direction |
| Name | Type | Description |
|---|---|---|
| Nicotine replacement therapy | DRUG | Nicotine replacement therapy with Standard NRT user direction |
Inclusion Criteria: * 18 years or older male and female cigarette smokers motivated and willing to stop smoking * female participants of child-bearing potential should use a medically acceptable means of birth control * evidence of a personally signed and dated informed consent document indicating ...
Nicotine replacement therapy is used for smoking cessation. It is a small molecule treatment being developed by Johnson & Johnson (ticker: JNJ) for people who want to quit smoking. The therapy is in Phase 2 clinical development and has been studied in adults aged 18 years and older.
Nicotine replacement therapy works as an agonist at the CHRNB2 and CHRNA4 targets. By acting on these nicotinic acetylcholine receptor subunits, it is designed to help manage nicotine withdrawal and craving during smoking cessation. This mechanism is distinct from simply delivering nicotine without receptor selectivity.
Johnson & Johnson, which trades under the ticker JNJ, is the developer of this nicotine replacement therapy. The company is responsible for advancing the program, which is currently in Phase 2 clinical development for smoking cessation.
Nicotine replacement therapy is in Phase 2 clinical development. It is an investigational treatment and has not been approved by the FDA. The program has completed one Phase 2 trial and currently has no active trials listed.
Nicotine replacement therapy has been evaluated in one completed Phase 2 trial, NCT00764439, titled "Pilot Study of a New Nicotine Replacement Therapy." The trial enrolled 258 participants in the United Kingdom, was randomized and active-controlled, and included adults 18 years and older of all sexes.