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Imonogas

Phase 3

Functional Dyspepsia | Small molecule | Other |Johnson & Johnson|Last Updated: Dec 15, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment210
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02660372Efficacy and Safety of Two Simeticone Brands in Adults With Functional DyspepsiaPHASE3 COMPLETED 210Feb 1, 2016Dec 1, 2016Dec 15, 20161 Russia
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Study Endpoints
Primary Endpoints
Aggregate symptom score calculated from subjects assessment of 10 individual upper gastrointestinal symptoms 8 weeks after start of treatments
8 weeks

Specific questionnaire with a 4 point scale

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Study Design & Arms
AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
ImonogasEXPERIMENTALImonogas 120 mg, 1 capsule three times daily for 8 weeks
EspumisanACTIVE_COMPARATOREspumisan 40 mg, 2 capsules four times daily for 8 weeks
Interventions
NameTypeDescription
ImonogasDRUGSimethicone 120 mg in gel capsules
EspumisanDRUGSimethicone 40 mg in gel capsules
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: 1. Subjects of the age of 18 years or older with a suspected diagnosis of functional dyspepsia according to Rome III criteria (see Appendix A) e.g. subjects suffering from bothersome postprandial fullness or early satiation or epigastric pain or epigastric burning AND no evidenc...

Countries:Russia
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