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Glucocorticoid

Phase 1

Prostate Neoplasms | Small molecule | Oncology |Johnson & Johnson|Last Updated: Apr 19, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLED
Total Trials1
Total Enrollment54
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01664728An Expanded Access Study of Abiraterone Acetate in Patients With Advanced Prostate Cancer Who Have Completed Clinical Study COU-AA-001PHASE1 COMPLETED 54Apr 1, 2007Sep 1, 2012Apr 19, 20131 United Kingdom
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Study Endpoints
Primary Endpoints
Number of participants with serum prostate specific antigen (PSA) decline according to PSA Working Group criteria
Screening, Cycle 1 Day 1 Pre-dose, every 3 months up to 3 years after study entry
Overall survival
every 3 months up to 3 years after study entry
Secondary Endpoints
Number of participants with adverse events
up to 30 days after the last dose of study medication
Time to disease progression
every 3 months up to 3 years after study entry
Time to prostate specific antigen progression
every 3 months up to 3 years after study entry
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Abiraterone acetateEXPERIMENTAL -
Interventions
NameTypeDescription
Abiraterone acetateDRUGPhase 2 maximum tolerated dose from Study COU-AA-001 taken orally once daily
GlucocorticoidDRUGprednisolone/prednisone 5 mg taken orally twice daily or dexamethasone 0.5 mg taken orally once daily
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Eligibility Criteria
Age Range18 Years — N/A
SexMALE
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Completed 12 cycles of abiraterone acetate under study COU-AA-001 * Last dose of abiraterone acetate within 14 days prior to treatment in this study * Demonstrates potential to gain clinical benefit with continued abiraterone acetate treatment * Serum potassium level \>=3.5 mm...

Countries:United Kingdom
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