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JZP926

Phase 2

Juvenile Myoclonic Epilepsy | Small molecule | Neurology |Jazz Pharmaceuticals plc|Last Updated: Sep 2, 2026

Target and mechanism

ModalitySmall molecule

Also known as JZP926 capsule

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment260

FDA Designations

No designations recorded

Clinical trial landscape

JZP926 · 1 trial · 1 indication

Phase 2 1
NCT07723963A Study to Evaluate the Safety and Efficacy of JZP926 Capsule for the Treatment of Juvenile Myoclonic EpilepsyJuvenile Myoclonic Epilepsy
NOT YET_RECRUITING260 Analytics
PHASE2NOT YET_RECRUITING
A Study to Evaluate the Safety and Efficacy of JZP926 Capsule for the Treatment of Juvenile Myoclonic Epilepsy
Juvenile Myoclonic EpilepsyUnlock trial analytics

Study Endpoints

Primary Endpoints

Change from baseline in myoclonic seizure days per 28 days (Part A and Part B)
Baseline up to end of 16 weeks treatment period

Secondary Endpoints

Patient and Caregiver Global Impression of Change in Usual Daily Activities (P/CaGI-C UDA) (Part A and Part B)
Week 16
Proportion of participants who achieve ≥ 50% and ≥ 75% reduction from baseline in myoclonic seizure days (Part A and Part B)
Baseline up to end of 16 weeks treatment period
Change from baseline in days with any seizure type per 28 days (Part A and Part B)
Baseline up to end of 16 weeks treatment period
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
JZP926 CapsuleEXPERIMENTALParticipants with JME will be randomized to JZP926 capsule based on weight-tiered dosing for a 16-week treatment period.
PlaceboPLACEBO_COMPARATORParticipants with JME will be randomized to matching placebo based on weight-tiered dosing for a 16-week treatment period.
Open-Label Extension: JZP926 CapsuleEXPERIMENTALParticipants completing Part A or Part B will have the option to continue into an open-label extension for up to 52 weeks, inclusive of a 4 week blinded transition.

Interventions

NameTypeDescription
JZP926 capsuleDRUGOral administration BID according to body weight
PlaceboDRUGOral administration BID according to body weight
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Eligibility Criteria

Age Range10 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites19

Inclusion Criteria Participants are eligible to be included in the study only if all of the following criteria apply: 1. Is ≥ 10 years of age at the time of screening. 2. Has a diagnosis of JME per ILAE criteria as specified in the protocol. 3. Has at least 4 myoclonic seizure days per 28 days his...

Countries:United States
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Recent Changes (Last 90 Days)

LOWSep 2, 2026NCT07723963startDate: changed
LOWSep 2, 2026NCT07723963startDate: changed
LOWSep 2, 2026NCT07723963startDate: changed
LOWJul 24, 2026NCT07723963NEW_TRIAL: changed
LOWJul 24, 2026NCT07723963NEW_TRIAL: changed

Frequently asked questions about JZP926

What is JZP926 used for?

JZP926 is an investigational small molecule being developed for the treatment of Juvenile Myoclonic Epilepsy, a form of epilepsy that typically begins in adolescence. It is currently in Phase 2 clinical development and has not been approved by regulatory authorities.

Who makes JZP926?

JZP926 is being developed by Jazz Pharmaceuticals plc, a biopharmaceutical company traded on the NASDAQ under the ticker symbol JAZZ. The company is conducting clinical trials to evaluate the safety and efficacy of JZP926 for Juvenile Myoclonic Epilepsy.

What phase is JZP926 in?

JZP926 is in Phase 2 clinical development. It is an investigational drug and has not yet been approved by the FDA or any other regulatory agency. The ongoing Phase 2 trial is designed to evaluate its safety and efficacy in patients with Juvenile Myoclonic Epilepsy.

What clinical trials is JZP926 in?

JZP926 is being studied in a Phase 2 clinical trial registered as NCT07723963. This randomized, double-blind, placebo-controlled study is evaluating the safety and efficacy of JZP926 capsules for the treatment of Juvenile Myoclonic Epilepsy. The trial is not yet recruiting and plans to enroll 260 participants in the United States.

Is JZP926 the same as JZP926 capsule?

Yes, JZP926 and JZP926 capsule refer to the same investigational drug. The capsule is the oral formulation being tested in clinical trials for Juvenile Myoclonic Epilepsy. The drug is being developed by Jazz Pharmaceuticals and is currently in Phase 2 testing.