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Testosterone enanthate

Phase 3

Hypogonadism, Male | Small molecule | Endocrine |Halozyme Therapeutics, Inc.|Last Updated: Feb 18, 2026

Target and mechanism

Molecular targetAR
Target classAgonist
ModalitySmall molecule

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment100

FDA Designations

No designations recorded

Clinical trial landscape

Testosterone enanthate · 1 trial · 1 indication

Phase 3 1
NCT0668908552 Week Study + 24-Month Long-Term Extension of Safety, PK, & Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents With HypogonadismHypogonadism, Male
RECRUITING100 Analytics
PHASE3RECRUITING
52 Week Study + 24-Month Long-Term Extension of Safety, PK, & Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents With Hypogonadism
Hypogonadism, MaleUnlock trial analytics

Study Endpoints

Primary Endpoints

Increase in testosterone, as evaluated using PK parameters
From Enrollment through End of Study Assessments at Week 53

Secondary Endpoints

Percentage of participants demonstrating either progression through Tanner Stages of puberty or attainment of Tanner Stage 5 by the end of the study
End of Study Assessment at Week 53
• Percentage of patients that had an increase in stretched penile length
End of Study Assessment at Week 53
Change from Screening or Baseline in DEXA bone density for total body less head (TBLH) and PA spine
End of Study Assessment at Week 53
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ParticipantsEXPERIMENTALXYOSTED Injection (Testosterone enanthate) 25 mg / 0.5 mL, 50 mg / 0.5 mL, 75 mg / 0.5 mL, 100 mg / 0.5 mL

Interventions

NameTypeDescription
Testosterone enanthateCOMBINATION_PRODUCTXYOSTED 25 mg / 0.5 mL; XYOSTED 50 mg / 0.5 mL; XYOSTED 75 mg / 0.5 mL; XYOSTED 100 mg / 0.5 mL
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Eligibility Criteria

Age Range12 Years to 17 Years
SexMALE
Healthy VolunteersNo
Study Sites20

Inclusion Criteria: 1. Diagnosed with a deficiency or absence of endogenous testosterone due to primary or secondary hypogonadism of a known etiology. Children with combined hormone deficiencies are permitted to enroll (but the child must already be receiving treatment for concomitant hormonal defi...

Countries:United States
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Frequently asked questions about Testosterone enanthate

What is Testosterone enanthate used for?

Testosterone enanthate is used for testosterone replacement therapy in male adolescents with hypogonadism. It is being studied in a Phase 3 clinical trial to evaluate its safety, pharmacokinetics, and efficacy in this patient population. The drug is administered to address the symptoms associated with low testosterone levels in adolescent males.

Who makes Testosterone enanthate?

Testosterone enanthate is being developed by Halozyme Therapeutics, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol HALO. The company is conducting a Phase 3 clinical trial to assess the drug's safety and efficacy in male adolescents with hypogonadism.

What phase is Testosterone enanthate in?

Testosterone enanthate is currently in Phase 3 clinical development. It is an investigational drug being studied for the treatment of male hypogonadism in adolescents. The ongoing Phase 3 trial is recruiting participants and is designed to evaluate the drug's safety, pharmacokinetics, and efficacy over a 52-week treatment period followed by a 24-month long-term extension.

What clinical trials is Testosterone enanthate in?

Testosterone enanthate is being evaluated in a Phase 3 clinical trial with the identifier NCT06689085. This study is a 52-week study with a 24-month long-term extension, focusing on the safety, pharmacokinetics, and efficacy of the drug for testosterone replacement in male adolescents with hypogonadism. The trial is currently recruiting participants in the United States.

Is Testosterone enanthate FDA approved?

Testosterone enanthate is not FDA approved for the indication being studied. It is an investigational drug currently in Phase 3 clinical development for the treatment of male hypogonadism in adolescents. The ongoing clinical trial is designed to gather data on its safety and efficacy, which would be necessary for regulatory approval.

How does Testosterone enanthate work?

Testosterone enanthate is a small molecule that works by providing exogenous testosterone to replace deficient endogenous levels in males with hypogonadism. By supplementing testosterone, the drug aims to restore normal physiological levels and alleviate symptoms associated with low testosterone, such as delayed puberty and other hypogonadal manifestations.