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Paxil

Phase 1

Depressive Disorder | Small molecule | Other |GSK plc|Last Updated: Aug 4, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedUNCONTROLLEDBiomarker
Total Trials1
Total Enrollment166
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00749359PAXIL CR Bioequivalence StudyPHASE1 COMPLETED 166Jul 7, 2008Sep 16, 2008Aug 4, 20172 United States
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Study Endpoints
Primary Endpoints
Paroxetine blood levels
measured up to 168 hours after a single dose.
Secondary Endpoints
Additional pharmacokinetic parameters related to blood levels of paroxetine . Safety & tolerability measures including ae reporting & vitals signs & ECGs
measured up to 168 hours after a single dose and throughout study
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeDIAGNOSTIC
Treatment Arms
ArmTypeDescription
open label treatmentEXPERIMENTALOn each treatment period, subjects will receive controlled release paroxetine 37.5 milligram (mg) on Day 1.
Interventions
NameTypeDescription
Paxil CRDRUGPaxil CR 37mg tablet manufactures at two different sites
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersYes
Study Sites2

Key Inclusion: Healthy males or females between 18-65. Body weight 50 kg (110 lbs) or higher, and BMI within the range 19-30 kg/m2. Willing to use acceptable forms of birth control throughout the study. Normal labs and ECG. Key Exclusion: Positive test for drugs or alcohol. Positive for Hepatitis...

Countries:United States
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