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VQW-765

Phase 3

Social Anxiety Disorder (SAD) | Small molecule | Psychiatry |Vanda Pharmaceuticals Inc.|Last Updated: Jul 20, 2026

Success Probability
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Market & Valuation
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment500
FDA Designations
No designations recorded
Clinical trial landscape

VQW-765 · 2 trials · 2 indications

Phase 3 1Phase 2 1
NCT07221578Study to Evaluate the Efficacy and Safety of VQW-765 for the On-Demand Treatment of Social Anxiety DisorderSocial Anxiety Disorder (SAD)
ACTIVE NOT_RECRUITING500 Analytics
PHASE3ACTIVE NOT_RECRUITING
Study to Evaluate the Efficacy and Safety of VQW-765 for the On-Demand Treatment of Social Anxiety Disorder
Social Anxiety Disorder (SAD)Unlock trial analytics
Study Endpoints
Primary Endpoints
Subjective Units of Distress Scale (SUDS)
1 day

Subjective Units of Distress Scale (SUDS) during performance phase, scored from 0-100 with a higher score indicating higher distress.

Secondary Endpoints
Subjective Units of Distress Scale (SUDS)
1 day
State-Trait Anxiety Inventory - State Anxiety Scale (STAI-S)
1 day
Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
2 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
VQW-765EXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -
Interventions
NameTypeDescription
VQW-765DRUGoral capsule
PlaceboDRUGoral capsule
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Eligibility Criteria
Age Range18 Years to 65 Years
SexALL
Healthy VolunteersNo
Study Sites30

Inclusion Criteria: 1. Ability and willingness to provide written informed consent. 2. Male and female subjects aged 18-65 years, inclusive. 3. Current diagnosis of social anxiety disorder. 4. Liebowitz Social Anxiety Scale total score ≥60. 5. Public Speaking Anxiety Scale total score ≥60. 6. Hamil...

Countries:United States
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Recent Changes (Last 90 Days)
MEDIUMJul 20, 2026NCT07221578Status: RECRUITING → ACTIVE_NOT_RECRUITING
MEDIUMJul 20, 2026NCT07221578Status: RECRUITING → ACTIVE_NOT_RECRUITING
LOWJun 25, 2026NCT07221578lastUpdatePostDate: changed
LOWJun 25, 2026NCT07221578lastUpdatePostDate: changed
LOWJun 25, 2026NCT07221578lastUpdatePostDate: changed
LOWMay 29, 2026NCT07221578lastUpdatePostDate: changed
LOWMay 29, 2026NCT07221578lastUpdatePostDate: changed
LOWMay 29, 2026NCT07221578lastUpdatePostDate: changed
LOWMay 26, 2026NCT07221578primaryCompletionDate: changed
LOWMay 24, 2026NCT07221578studyFirstPostDate: changed