Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Also known as Travoprost Intracameral Implant exchanged at Month 12
Travoprost Intracameral exchanged at Month 12 · 1 trial · 2 indications
concentration of travoprost free acid (ng/mL) in the aqueous humor 12 months post-administration as assessed by liquid chromatography tandem mass spectrometry (LC-MS/MS)
concentration of travoprost free acid (ng/mL) in the aqueous humor 3 months post-administration as assessed by LC-MS/MS
concentration of travoprost free acid (ng/mL) in the aqueous humor 6 months post-administration as assessed by LC-MS/MS
concentration of travoprost free acid (ng/mL) in the aqueous humor 24 months post-administration as assessed by LC-MS/MS
concentration of travoprost free acid (ng/mL) in the aqueous humor 21 months post-administration as assessed by LC-MS/MS
concentration of travoprost free acid (ng/mL) in the aqueous humor 18 months post-administration as assessed by LC-MS/MS
concentration of travoprost free acid (ng/mL) in the aqueous humor 15 months post-administration as assessed by LC-MS/MS
| Arm | Type | Description |
|---|---|---|
| Cohort 1 (12-month exchange) | EXPERIMENTAL | Travoprost Intracameral Implant Exchanged at Month 12 |
| Cohort 2 (3-month exchange) | EXPERIMENTAL | Travoprost Intracameral Implant Exchanged at Month 3 |
| Cohort 3 (6-month exchange) | EXPERIMENTAL | Travoprost Intracameral Implant Exchanged at Month 6 |
| Cohort 4 (24-month exchange) | EXPERIMENTAL | Travoprost Intracameral Implant Exchanged at Month 24 |
| Cohort 5 (21-month exchange) | EXPERIMENTAL | Travoprost Intracameral Implant Exchanged at Month 21 |
| Cohort 6 (18-month exchange) | EXPERIMENTAL | Travoprost Intracameral Implant Exchanged at Month 18 |
| Cohort 7 (15-month exchange) | EXPERIMENTAL | Travoprost Intracameral Implant Exchanged at Month 15 |
| Name | Type | Description |
|---|---|---|
| Travoprost Intracameral Implant exchanged at Month 12 | DRUG | intracameral implant containing travoprost 75 mcg implanted on Day 1 and exchanged at Month 12 |
| Travoprost Intracameral Implant exchanged at Month 3 | DRUG | intracameral implant containing travoprost 75 mcg implanted on Day 1 and exchanged at Month 3 |
| Travoprost Intracameral Implant exchanged at Month 6 | DRUG | intracameral implant containing travoprost 75 mcg implanted on Day 1 and exchanged at Month 6 |
| Travoprost Intracameral Implant exchanged at Month 24 | DRUG | intracameral implant containing travoprost 75 mcg implanted on Day 1 and exchanged at Month 24 |
| Travoprost intracameral implant exchanged at Month 21 | DRUG | intracameral implant containing travoprost 75 mcg implanted on Day 1 and exchanged at Month 21 |
| Travoprost intracameral implant exchanged at Month 18 | DRUG | intracameral implant containing travoprost 75 mcg implanted on Day 1 and exchanged at Month 18 |
| Travoprost intracameral implant exchanged at Month 15 | DRUG | intracameral implant containing travoprost 75 mcg implanted on Day 1 and exchanged at Month 15 |
Inclusion Criteria: * Diagnosis of either open angle glaucoma (i.e. primary, pseudoexfoliation, or pigmentary glaucoma) or ocular hypertenson * Zero to three topical intraocular pressure lowering medications at the time of Visit 1 (Screening) exam. * Best spectacle corrected visual acuity of 16 let...