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HuMax-CD4

Phase 2

T Cell Lymphoma | Monoclonal antibody | Oncology |Emergent BioSolutions Inc.|Last Updated: Mar 18, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedUNCONTROLLEDBiomarker
Total Trials1
Total Enrollment21
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00877656HuMax-CD4 in Non-Cutaneous T-Cell LymphomaPHASE2 COMPLETED 21Aug 1, 2005Dec 1, 2008Mar 18, 2024 -
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Study Endpoints
Primary Endpoints
Efficacy as measured by survival and time to disease progression
12 months
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
CD4EXPERIMENTALOpen label treatment arm
Interventions
NameTypeDescription
HuMax-CD4BIOLOGICALActive treatment
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Diagnostic biopsy of non cutaneous T Cell lymphoma with positive phenotype * Relapsed or refractory to minimum of one course of chemotherapy * Study is closed to enrollment.

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Competitive Landscape -Cutaneous T-Cell Lymphoma 4 trials