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Oritavancin

Phase 1

Gram-positive Bacterial Infections | Small molecule | Infectious Disease |CorMedix Inc.|Last Updated: Dec 12, 2025

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment41
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02134301Open Label, Dose-finding, Pharmacokinetics, Safety and Tolerability Study of Oritavancin in Pediatric Participants With Suspected or Confirmed Bacterial InfectionsPHASE1 COMPLETED 41May 1, 2014Nov 4, 2025Dec 12, 20258 United States
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Study Endpoints
Primary Endpoints
Pharmacokinetic Parameter (Area under the plasma concentration time-curve [AUC])
336 hours post infusion start time for Cohorts 1-4 and 168 hours for Cohort 5

PK parameters (AUC)

Secondary Endpoints
Pharmacokinetic Parameters
336 hours post infusion start time for Cohorts 1-4 and 168 hours for Cohort 5
Safety Endpoint
Up to Day 60 post-dose
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
OritavancinEXPERIMENTALSingle-dose IV Oritavancin Diphosphate
Interventions
NameTypeDescription
OritavancinDRUG -
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Eligibility Criteria
Age RangeN/A — 18 Years
SexALL
Healthy VolunteersNo
Study Sites8

Inclusion Criteria: * Males and females \<18 years of age. * Neonates must be at least 34 weeks post-conception age. * Parent or legal guardian has given informed consent, as appropriate; and pediatric participant has given verbal assent where appropriate. * Suspected or diagnosed Gram-positive bac...

Countries:United States
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