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Hydromorphone

Phase 2

Fracture | Small molecule | Musculoskeletal |The Cooper Companies, Inc.|Last Updated: Feb 23, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLED
Total Trials1
Total Enrollment48
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07430345Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department: a Randomized Controlled StudyPHASE1/PHASE2 NOT YET_RECRUITING 48Apr 1, 2026Jan 1, 2027Feb 23, 2026 -
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Study Design & Arms
Interventions
NameTypeDescription
Buprenorphine 0.15 MGDRUGgiven every 15 minutes as needed for numerical pain score 4 or greater for a maximum of three doses
Hydromorphone 0.25 mg IVDRUGgiven every 15 minutes as needed for numerical pain score 4 or greater for a maximum of three doses
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Competitive Landscape -Fractures 35 trials
Recent Changes (Last 90 Days)
LOWMay 24, 2026NCT07430345studyFirstPostDate: changed