Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
CBG Cannabis · 1 trial · 1 indication
Subjective drug effect ratings (0-100) will be collected with the Drug Effect Questionnaire, with 0 being no effect and 100 being maximum effect.
Heart rate (beats/minute) will be measured while sitting down using the vitals machine.
Blood pressure (mmHg) will be measured while sitting down using the vitals machine.
Divided Attention Task (DAT), cognitive task administered on the computer to assess divided attention.
Digit Symbol Substitution Task, cognitive task administered to assess response speed, sustained attention, visual spatial skills and set shifting.
Paced Auditory Serial Addition Task, cognitive task that measures cognitive function by assessing auditory information processing speed and flexibility, as well as calculation ability.
Composite score on the DRUID App, a measure of behavioral task performance (range 0-100) where lower scores indicate better performance.
Digit Vigilance Test, primary outcome is response time of all trials.
Digit Vigilance Test, primary outcome is number of incorrect responses of all trials.
Go/No-Go Task, primary outcome is response time of all trials.
Go/No-Go Task, primary outcome is number of incorrect responses of all trials.
Blood is collected through an intravenous catheter, quantitative results are reported in nanograms per milliliter (ng/ml).
Urine is provided by participant, quantitative results are reported in nanograms per milliliter (ng/ml).
| Arm | Type | Description |
|---|---|---|
| Placebo | PLACEBO_COMPARATOR | Single acute administration of oral Placebo liquid (MCT oil). |
| Oral administration of 25mg CBG | EXPERIMENTAL | Single acute administration of 25mg CBG suspended in MCT oil. |
| Oral administration of 50mg CBG | EXPERIMENTAL | Single acute administration of 50mg CBG suspended in MCT oil. |
| Oral administration of 100mg CBG | EXPERIMENTAL | Single acute administration of 100mg CBG suspended in MCT oil. |
| Oral administration of 200mg CBG | EXPERIMENTAL | Single acute administration of 200mg CBG suspended in MCT oil. |
| Name | Type | Description |
|---|---|---|
| Oral Placebo | DRUG | Placebo will be orally self-administered by study participants. |
| Oral CBG Cannabis | DRUG | CBG cannabis oil will be orally self-administered by study participants. |
Inclusion Criteria: 1. Have provided written informed consent. 2. Be between the ages of 18 and 55. 3. Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests. 4. Test negative for recent cannabis use in urine at the screening vis...