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Oxymorphone IR

Phase 3

Post-operative Pain | Small molecule | Pain |BrainsWay Ltd.|Last Updated: Feb 27, 2019

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment122

FDA Designations

No designations recorded

Clinical trial landscape

Oxymorphone IR · 2 trials · 2 indications

Phase 3 2
NCT00801398Open-Label Safety and Tolerability Study of Oxymorphone for Acute Postoperative Pain in Pediatric Subjects.Postoperative Pain
COMPLETED58 Analytics
NCT00904085Post-operative Efficacy and Safety StudyPost-operative Pain
COMPLETED122 Analytics
PHASE3COMPLETED
Open-Label Safety and Tolerability Study of Oxymorphone for Acute Postoperative Pain in Pediatric Subjects.
Postoperative PainUnlock trial analytics
PHASE3COMPLETED
Post-operative Efficacy and Safety Study
Post-operative PainUnlock trial analytics

Study Endpoints

Primary Endpoints

Summary of Visual Analog Scales (VAS) of Pain Intensity Change From Baseline by Treatment Group With Single Dose of Oxymorphone IR Tablet and Multiple Dose of Oxymorphone IR Tablet
Single Dose Timeframe: 15min, 30min, 1h, 2h, 3h, 4h, 6h or Rescue; Multiple Dose Timeframe: 15min, 30min, 1h, 2h, 3h, 4h, 6h, subsequent doses every 4-6 hours (Multiple Dose #1-11), and Early Termination

Change from Baseline in 100-mm Visual Analog Scales (VAS) in Multiple Dose of Oxymorphone IR Tablet

Subjects Taking Rescue Medication
first dose through 48 hours after first dose

Percentages are based on the number of subjects in each treatment group.

Sum of Pain Intensity (SPID) Visual Analog Scale (VAS)
2 months

Secondary Endpoints

AUC(0-t) of Single Dose of Oxymorphone by Treatment Group
Baseline, 2h, 4h, 8h, 12h, 24h, 28h, 32h, 36h and 48h
AUC(0-inf) of Single Dose of Oxymorphone by Treatment Group
Baseline, 2h, 4h, 8h, 12h, 24h, 28h, 32h, 36h and 48h
Cmax of Single Dose of Oxymorphone by Treatment Group
Baseline, 2h, 4h, 8h, 12h, 24h, 28h, 32h, 36h and 48h
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Oxymorphone IREXPERIMENTALOpen-Label, 2 part ascending-dose multicenter study
OxymorphoneACTIVE_COMPARATOR -
PlaceboPLACEBO_COMPARATOR -

Interventions

NameTypeDescription
Oxymorphone IRDRUGOpen-label, 2 part, ascending dose, single and multiple dose q4-6 hrs up to 48 hrs
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Eligibility Criteria

Age Range12 Years to 17 Years
SexALL
Healthy VolunteersYes
Study Sites11

Inclusion Criteria: * Male or female \> 12 to 17 years of age, inclusive * Weigh at least 50 kg * Postoperative oral opioid analgesia required for at least 24 hours or 48 hours following postoperataive parenteral analgesia * Are expected to be hospitalized for the duration of the study Exclusion C...

Countries:United States
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Frequently asked questions about Oxymorphone IR

What is Oxymorphone IR used for?

Oxymorphone IR is an immediate-release small molecule opioid being studied for the treatment of postoperative pain and post-operative pain. It is currently in Phase 3 clinical development and is not yet approved by the FDA.

Who makes Oxymorphone IR?

Oxymorphone IR is being developed by BrainsWay Ltd., a company publicly traded under the ticker BWAY. The drug is in Phase 3 clinical trials for postoperative pain.

What phase is Oxymorphone IR in?

Oxymorphone IR is in Phase 3 clinical development. It is an investigational drug and has not been approved by the FDA. Two Phase 3 trials have been completed for postoperative pain.

What clinical trials is Oxymorphone IR in?

Oxymorphone IR has been studied in two completed Phase 3 trials: NCT00801398, an open-label safety study in pediatric subjects with postoperative pain, and NCT00904085, a post-operative efficacy and safety study in adults.

Is Oxymorphone IR the same as oxymorphone?

Oxymorphone IR is an immediate-release formulation of oxymorphone, an opioid analgesic. The drug is being studied for acute postoperative pain, with trials including a pediatric safety study and an adult efficacy study.