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CV9103

Phase 1

Hormonal Refractory Prostate Cancer | Monoclonal antibody | Oncology |BioNTech SE|Last Updated: Mar 20, 2018

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment48
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00831467Safety and Efficacy Trial of a RNActive®-Derived Prostate Cancer Vaccine in Hormone Refractory DiseasePHASE1 COMPLETED 48Jan 1, 2009Sep 1, 2013Mar 20, 201812 Germany, Italy
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Study Endpoints
Primary Endpoints
Determination of the recommended dose for exploration in the phase II part
6-9 months
Assessment of Safety of trial regimen
2 years
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
CV9103EXPERIMENTALCV9103 is applied intradermally into the thigh and upper arm of either side of the body at week 1, week 3, week 7, week 15, week 23
Interventions
NameTypeDescription
CV9103BIOLOGICALOver a period of 23 weeks 5 vaccinations with CV9103 will be administered.
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Eligibility Criteria
Age Range18 Years — 75 Years
SexMALE
Healthy VolunteersNo
Study Sites12

Inclusion Criteria: * Signed informed consent in accordance with GCP and local regulatory requirements prior to trial participation * Male and age ≥ 18 years (Phase I and II) and ≤ 75 years (Phase II only) * Histologically confirmed diagnosis of adenocarcinoma of the prostate, Gleason Score availab...

Countries:GermanyItaly
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