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Loteprednol Etabonate

Phase 1

Eye Pain | Small molecule | Pain |Bausch Health Companies Inc.|Last Updated: Feb 24, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment15
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03063489Evaluation of the Safety, Systemic Pharmacokinetics, and TolerabilityPHASE1 COMPLETED 15Feb 1, 2015Jul 1, 2015Feb 24, 20176 United States
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Study Endpoints
Primary Endpoints
Blood samples will be collected for the determination of loteprednol etabonate concentrations in plasma samples
2 weeks
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeSUPPORTIVE_CARE
Treatment Arms
ArmTypeDescription
Loteprednol Etabonate Ophthalmic GelEXPERIMENTALFormulated LE into a gel (loteprednol etabonate ophthalmic gel, \[Lotemax® gel\])
Interventions
NameTypeDescription
Loteprednol Etabonate Ophthalmic GelDRUGFormulated LE into a gel (loteprednol etabonate ophthalmic gel, \[Lotemax® gel\])
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites6

Key Inclusion Criteria: * Are able to read, understand and provide written informed consent on an Informed Consent Form (ICF) approved by the Institutional Review Board (IRB)/Independent Ethics Committee (IEC). * Be a non-smoking male or female at least 18 years of age on the date the ICF is signed...

Countries:United States
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