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DL6049

Phase 3

Nasolabial Fold Wrinkles | Unknown | Other |Bausch Health Companies Inc.|Last Updated: Sep 18, 2019

Success Probability

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Market & Valuation

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Trial Design

RandomizedUNCONTROLLED
Total Trials2
Total Enrollment480

FDA Designations

No designations recorded

Clinical trial landscape

DL6049 · 2 trials · 1 indication

Phase 3 2
NCT00444353DL6049 Versus Cosmoplast in the Treatment of Nasolabial Fold Wrinkles, Long Term Follow-upNasolabial Fold Wrinkles
COMPLETED240 Analytics
NCT00444210DL6049 vs CosmoPlast in the Treatment of Nasolabial Fold WrinklesNasolabial Fold Wrinkles
COMPLETED240 Analytics
PHASE3COMPLETED
DL6049 Versus Cosmoplast in the Treatment of Nasolabial Fold Wrinkles, Long Term Follow-up
Nasolabial Fold WrinklesUnlock trial analytics
PHASE3COMPLETED
DL6049 vs CosmoPlast in the Treatment of Nasolabial Fold Wrinkles
Nasolabial Fold WrinklesUnlock trial analytics

Study Endpoints

Primary Endpoints

Evaluate degree of correction attainable with DL6049 compared to CosmoPlast Collagen Implant
in the treatment of dermal nasolabial fold wrinkles at 13 months following last application of study treatment.
Primary: Evaluate degree of correction attainable with DL6049 compared to CosmoPlast Collagen Implant; in the treatment of dermal nasolabial fold wrinkles at 13 months following last application of study treatment.

Secondary Endpoints

Treatment group comparisons at each timepoint of the treatment success rate (proportion of subjects with a photographic wrinkle severity grade of < 2), mean wrinkle severity grade, and investigator/subject global assessments.
Treatment group comparisons at each timepoint of the treatment success rate (proportion of subjects with a photographic wrinkle severity grade of < 2), mean wrinkle severity grade, and investigator/subject global assessment
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Study Design & Arms

AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
DL6049 (injectable poly-L-lactic acid)DEVICE -
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Eligibility Criteria

Age Range18 Years to 75 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Subjects must sign a statement of IC and HIPAA authorization. In addition subjects must provide a separate release for use of their photographs in publications; any subject has a right to refuse the photo release without jeopardizing their ability to participate in the study. ...

Countries:United States
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Frequently asked questions about DL6049

What is DL6049 used for?

DL6049 is an investigational product being studied for the treatment of nasolabial fold wrinkles, which are the lines that run from the sides of the nose to the corners of the mouth. It is currently in Phase 3 clinical development and is not yet approved by regulatory authorities.

Who makes DL6049?

DL6049 is being developed by Bausch Health Companies Inc., a company publicly traded under the ticker symbol BHC. The company is conducting clinical trials to evaluate the safety and effectiveness of DL6049 for nasolabial fold wrinkles.

What phase is DL6049 in?

DL6049 is in Phase 3 clinical development. It has completed two Phase 3 trials, and it remains an investigational drug, meaning it has not been approved for commercial use. The trials were conducted in the United States with adult participants.

What clinical trials is DL6049 in?

DL6049 has been studied in two completed Phase 3 clinical trials. The first trial, NCT00444210, compared DL6049 to CosmoPlast in the treatment of nasolabial fold wrinkles. The second trial, NCT00444353, was a long-term follow-up study comparing DL6049 to Cosmoplast for the same condition.

Is DL6049 the same as CosmoPlast?

No, DL6049 is not the same as CosmoPlast. In clinical trials, DL6049 was compared against CosmoPlast, which served as a comparator product. The trials were designed to evaluate how DL6049 performs relative to CosmoPlast in treating nasolabial fold wrinkles.