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Balsalazide Disodium

Phase 3

Inflammatory Bowel Disease | Small molecule | Immunology |Bausch Health Companies Inc.|Last Updated: Nov 25, 2019

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindUNCONTROLLEDBiomarker
Total Trials2
Total Enrollment843
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00486031Open-Label, Long-term Balsalziade Disodium Tablet Ulcerative Colitis StudyPHASE3 COMPLETED 443Oct 1, 2006Dec 1, 2008Aug 15, 201995 United States
NCT00408174Balsalazide Disodium vs. Mesalamine in Mildly to Moderately Active Ulcerative ColitisPHASE3 COMPLETED 400May 1, 2006Nov 1, 2007Nov 25, 201988 United States
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Study Endpoints
Primary Endpoints
Incidence of Treatment Emergent AEs
24 Months

Incidence of treatment emergent adverse events

The primary efficacy endpoint is the proportion of subjects that achieve clinical improvement and improvement in the rectal bleeding subscale of the MMDAI at the end of six weeks of therapy.
Secondary Endpoints
Time to Onset of AEs
24 Months
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeSUPPORTIVE_CARE
Treatment Arms
ArmTypeDescription
balsalazide disodium tablets,3.3 g BID,OTHER -
Interventions
NameTypeDescription
Balsalazide DisodiumDRUG -
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites95

Inclusion Criteria: * Subject has a documented history of UC and is either in remission or currently presents with mildly to moderately active UC symptoms as determined by the investigator upon subject interview of UC symptoms, (e.g., urgency, bowel frequency, and rectal bleeding). Additionally, th...

Countries:United States
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