Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
terbutaline · 2 trials · 2 indications
FEV1
| Arm | Type | Description |
|---|---|---|
| 1 | ACTIVE_COMPARATOR | Bricasol® |
| 2 | EXPERIMENTAL | Bricasol® + Pulmicort® |
| 3 | EXPERIMENTAL | Bricasol® + Symbicort® |
| A | ACTIVE_COMPARATOR | budesonide 400yg + terbutaline 0.4 mg as-needed |
| B | ACTIVE_COMPARATOR | placebo + terbutaline 0.4 mg as-needed |
| C | ACTIVE_COMPARATOR | placebo + budesonide/formoterol 160/4.5 yg as-needed |
| Name | Type | Description |
|---|---|---|
| budesonide/formoterol (Symbicort) | DRUG | inhalation therapy |
| budesonide (Pulmicort) | DRUG | inhalation |
| terbutaline sulfate (Bricasol) | DRUG | inhalation therapy |
| budesonide | DRUG | 400 yg x 1 |
| terbutaline | DRUG | 0.4 mg as-needed |
| budesonide/formoterol | DRUG | 160/4.5 yg as-needed |
Inclusion Criteria: * Signed and dated inform consent * Out-patient, clinical diagnosis of COPD * Men or women at the age of 40 or over Exclusion Criteria: * A history of asthma * Seasonal allergic rhinitis before 40 years of age * Patients with significant or unstable ischemic heart disease, arr...
Terbutaline is used for exercise induced asthma and chronic obstructive pulmonary disease (COPD). It is a small molecule respiratory therapy being developed by AstraZeneca PLC (AZN). In clinical studies, terbutaline has been evaluated as a bronchodilator for patients with these conditions.
Terbutaline is developed by AstraZeneca PLC, which trades under the ticker AZN. AstraZeneca is the company behind the clinical development of terbutaline for respiratory indications including exercise induced asthma and chronic obstructive pulmonary disease.
Terbutaline has been studied in Phase 3 clinical trials for chronic obstructive pulmonary disease and in Phase 2 trials for exercise induced asthma. It remains an investigational drug in clinical development, with completed trials but no approved status indicated in the available data.
Terbutaline has been studied in two completed clinical trials. NCT00421122 was a Phase 3 study in 315 Chinese patients with COPD, and NCT00989833 was a Phase 2 study in 66 patients with exercise induced asthma. Both trials were randomized, double blind, and active controlled.
Yes, terbutaline is the same as Bricanyl. In clinical trial NCT00989833, Bricanyl is referenced as a brand name for terbutaline used as-needed in asthma patients. This trial compared Bricanyl as-needed against other treatments for exercise induced asthma.