Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Metoprolol- Toprol XL · 1 trial · 1 indication
Assesment following multiple dosing of metoprolol CR/XL 200 mg once daily, or multiple dosing of metoprolol IR 200 mg daily in divided doses
Assesment following multiple dosing of metoprolol CR/XL 200 mg once daily, or multiple dosing of metoprolol IR 200 mg daily in divided doses
| Arm | Type | Description |
|---|---|---|
| Metoprolol- Toprol XL | EXPERIMENTAL | Metoprolol extended release (CR/XL) tablet 200 mg once daily |
| Metoprolol- Lopressor | ACTIVE_COMPARATOR | Metoprolol immediate release (IR) tablet |
| Name | Type | Description |
|---|---|---|
| Metoprolol- Toprol XL | DRUG | Extended release tablet, 200mg once daily for 4 days |
| Metoprolol- Lopressor | DRUG | Immediate release tablet, Day 1 50 mg four times daily, Day 2, 3 and 4 100 mg twice daily |
Inclusion Criteria: * Male and female patients admitted to the CCU with suspected acute myocardial infarction * Age 18 years or older * Treated with and tolerated the full dose of metoprolol IR 50 mr four times daily or metoprolol CR/XL 200 mg once daily on study day 1 * Expected to stay in the CCU...