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Iressa

Phase 2

Locally Advanced Prostate Cancer | Small molecule | Oncology |AstraZeneca PLC|Last Updated: Jan 25, 2011

Target and mechanism

Molecular targetEGFR
Target classInhibitor
ModalitySmall molecule
ChEMBLCHEMBL939

Also known as Gefitinib

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment102

FDA Designations

No designations recorded

Clinical trial landscape

Iressa · 1 trial · 1 indication

Phase 2 1
NCT00319787Combination Casodex® and Iressa™ in Locally Advanced Prostate CancerLocally Advanced Prostate Cancer
COMPLETED102 Analytics
PHASE2COMPLETED
Combination Casodex® and Iressa™ in Locally Advanced Prostate Cancer
Locally Advanced Prostate CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Determine the difference in the rate of PSA decrease between treatments over a 6 months period.

Secondary Endpoints

To detect changes in prostatic metabolites by using in vivo magnetic resonance spectroscopy (MRS)
To detect changes in prostate gland using magnetic resonance imaging (MRI)
To detect changes in serum tumor markers
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
IressaDRUG -
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Eligibility Criteria

Age Range18 Years to 80 Years
SexMALE
Healthy VolunteersNo
Study Sites3

Inclusion Criteria: * 18 to 80 years of age. Men with histologically confirmed locally advanced prostatic adenocarcinoma Exclusion Criteria: * No prior treatment for prostate cancer, including surgery, radiotherapy, cryotherapy or thermotherapy. No abnormal laboratory values. No co-existing malig...

Countries:Norway
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Frequently asked questions about Iressa

What is Iressa used for in locally advanced prostate cancer?

Iressa, also known as Gefitinib, is a small molecule being studied for the treatment of locally advanced prostate cancer. It is an investigational drug in Phase 2 clinical development, evaluated in combination with Casodex in a completed trial. The study enrolled 102 male participants aged 18 years and older in Norway.

What does Iressa target?

Iressa is a kinase inhibitor, belonging to the -tinib class of drugs. It targets and inhibits specific kinase enzymes involved in cancer cell growth and proliferation. This mechanism is being explored in the context of locally advanced prostate cancer, where it was tested in combination with Casodex in a Phase 2 clinical trial.

Who makes Iressa?

Iressa is developed by AstraZeneca PLC, a multinational pharmaceutical company listed on the stock exchange under the ticker AZN. The drug is being investigated for locally advanced prostate cancer, with a completed Phase 2 clinical trial assessing its efficacy and safety in combination with Casodex.

What phase is Iressa in?

Iressa is in Phase 2 clinical development for locally advanced prostate cancer. It is an investigational drug, not yet approved for this indication. The Phase 2 trial, NCT00319787, has been completed, and the drug is no longer in active clinical trials for this condition.

What clinical trials is Iressa in?

Iressa was studied in a single Phase 2 clinical trial, NCT00319787, titled 'Combination Casodex® and Iressa™ in Locally Advanced Prostate Cancer'. This completed trial enrolled 102 participants and was conducted in Norway. The study was randomized, double-blind, and uncontrolled, with a control type of uncontrolled.

Is Iressa the same as Gefitinib?

Yes, Iressa is the brand name for Gefitinib. The drug is also known by its generic name, Gefitinib. In clinical trials and medical literature, it may be referred to by either name. In the context of locally advanced prostate cancer, it is being investigated under the name Iressa.