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Bevespi

Phase 2

Chronic Obstructive Pulmonary Disease | Small molecule | Respiratory |AstraZeneca PLC|Last Updated: Apr 23, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLEDBiomarker
Total Trials1
Total Enrollment30

FDA Designations

No designations recorded

Clinical trial landscape

Bevespi · 1 trial · 1 indication

Phase 2 1
NCT05607719Inhaled Corticosteroids (ICS) on Pulmonary Endothelial Function in COPDChronic Obstructive Pulmonary Disease
ACTIVE NOT_RECRUITING30 Analytics
PHASE2ACTIVE NOT_RECRUITING
Inhaled Corticosteroids (ICS) on Pulmonary Endothelial Function in COPD
Chronic Obstructive Pulmonary DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Albuterol induced percent change in pulmonary vascular resistance (PVR)
baseline to 15 minutes post inhalation

Echocardiographic assessment of PVR before and after inhalation of 180 μg albuterol as a test of endothelial function

Secondary Endpoints

Albuterol induced absolute change in PVR
baseline, up to 45 minutes post inhalation
Percent change in FEV1
baseline to 15 minutes post inhalation
Change in oxygen saturation
baseline, up to 45 minutes post inhalation
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelCROSSOVER
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Bretzri followed by Bevespi GroupEXPERIMENTALParticipants in this group will receive Bretzri for 4-weeks followed by 8-weeks of Bevespi.
Bevespi followed by Bretzri GroupEXPERIMENTALParticipants in this group will receive Bevespi for 8-weeks followed by 4-weeks of Bretzri.

Interventions

NameTypeDescription
BevespiDRUGTwo puffs twice a day
BretzriDRUGTwo puffs twice a day
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Eligibility Criteria

Age Range40 Years to 80 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * physician diagnosis of COPD * former smoking history of more than 10 pack-years * baseline post-bronchodilator one-second forced expiratory volume (FEV1) 50-80% of predicted, baseline FEV1 and forced vital capacity (FVC) ratio \<0.7 * males and females, 40-80 years of age * re...

Countries:United States
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Frequently asked questions about Bevespi

What is Bevespi used for?

Bevespi is an investigational small molecule being developed for the treatment of Chronic Obstructive Pulmonary Disease (COPD). It is currently in Phase 2 clinical development and has not been approved by regulatory authorities.

Who makes Bevespi?

Bevespi is being developed by AstraZeneca PLC, a biopharmaceutical company listed on the stock exchange under the ticker symbol AZN. The company is conducting clinical trials to evaluate the drug's safety and efficacy in patients with COPD.

What phase is Bevespi in?

Bevespi is currently in Phase 2 clinical development. It is an investigational drug, meaning it has not yet received regulatory approval and is still being studied in clinical trials to assess its safety and effectiveness for treating COPD.

What clinical trials is Bevespi in?

Bevespi is being studied in a Phase 2 clinical trial with the identifier NCT05607719, titled 'Inhaled Corticosteroids (ICS) on Pulmonary Endothelial Function in COPD.' This randomized, double-blind, controlled trial is active but not recruiting, with an enrollment of 30 participants in the United States.

Is Bevespi the same as any other drug?

No alternative names for Bevespi have been disclosed. The drug is identified solely by its brand name in the available clinical trial information.