Recent Updates
Recently added Catalysts

Atropine

Phase 1

Insulin Resistance | Small molecule | Metabolic |AstraZeneca PLC|Last Updated: Mar 13, 2009

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedUNCONTROLLED
Total Trials1
Total Enrollment12

FDA Designations

No designations recorded

Clinical trial landscape

Atropine · 1 trial · 1 indication

Early Phase 1 1
NCT00689208Pharmacological Intervention in Insulin Resistance Targeting Autonomic Nerve ActivityInsulin Resistance
COMPLETED12 Analytics
EARLY_PHASE1COMPLETED
Pharmacological Intervention in Insulin Resistance Targeting Autonomic Nerve Activity
Insulin Resistance
NCT0068920812
Unlock trial analytics

Study Endpoints

Primary Endpoints

Study the effect of anticholinergic drugs on insulin sensitivity by assessment of glucose infusion rate during hyperinsulinemic euglycemic clamp.
After Insulin bolus, following will be measured; p-glucose (every 5 minutes), blood samples (every 30 minutes), pulse (every 5 minutes the first hour then every 10 minutes), blood pressure will be measured (the same as pulse).

Secondary Endpoints

Study the effect of cholinergic stimulation on insulin sensitivity by assessment ofglucose infusion rate during hyperinsulinemic euglycemic clamp.
measured; p-glucose (every 5 minutes), blood samples (every 30 minutes), pulse (every 5 minutes the first hour then every 10 minutes), blood pressure will be measured (the same as pulse).
Study the possible difference in effect of cholinergic (physostigmine) andanticholinergic (atropine) drugs on insulin sensitivity in a lean and abdominal obese subgroup of subjects.
measured; p-glucose (every 5 minutes), blood samples (every 30 minutes), pulse (every 5 minutes the first hour then every 10 minutes), blood pressure will be measured (the same as pulse).
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingSINGLE
ModelCROSSOVER
PurposeBASIC_SCIENCE

Interventions

NameTypeDescription
AtropineDRUG10 ug/kg bolus, 4 ug/kg/h infusion
PhysostigmineDRUG0,12ug/kg/min
Placebo SodiumDRUG -
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to 60 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Signed written informed consent * BMI of lean and abdominally obese men and women * weight stable Exclusion Criteria: * Ongoing clinically significant diseases * History of repeated syncope * resting pulse\<50 or systolic blood pressure \<100

Countries:Sweden
Unlock Eligibility Criteria

Frequently asked questions about Atropine

What is Atropine used for in insulin resistance?

Atropine is being investigated for use in insulin resistance, a metabolic condition. It is a small molecule being developed by AstraZeneca PLC. The drug is in early clinical development, with a completed Phase 1 trial studying its effects on autonomic nerve activity in insulin resistance.

What does Atropine target?

Atropine targets the autonomic nervous system, specifically modulating autonomic nerve activity. This mechanism is being studied in the context of insulin resistance, where autonomic dysfunction may play a role. The drug is a small molecule designed to intervene in this pathway.

Who makes Atropine?

Atropine is being developed by AstraZeneca PLC, a multinational pharmaceutical company listed on the stock exchange under the ticker AZN. AstraZeneca is conducting clinical research on Atropine for the treatment of insulin resistance, a metabolic disorder.

What phase is Atropine in?

Atropine is in Phase 1 clinical development for insulin resistance. The drug is investigational and has not been approved by regulatory authorities. A single early Phase 1 trial has been completed, involving 12 participants, to assess its pharmacological effects.

What clinical trials is Atropine in?

Atropine has one completed clinical trial registered under NCT00689208, titled 'Pharmacological Intervention in Insulin Resistance Targeting Autonomic Nerve Activity.' This early Phase 1 study enrolled 12 healthy volunteers in Sweden and was completed, with no active trials currently ongoing.

Is Atropine the same as atropine sulfate?

Atropine is the base compound, and atropine sulfate is a salt form commonly used in medical formulations. In the context of this clinical development program, the drug is referred to as Atropine, and no alternative names have been specified in the trial data.