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AZD8330

Phase 1

Cancer | Small molecule | Oncology |AstraZeneca PLC|Last Updated: Aug 24, 2011

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment83

FDA Designations

No designations recorded

Clinical trial landscape

AZD8330 · 1 trial · 1 indication

Phase 1 1
NCT00454090AZD8330 First Time in Man in Patients With Advanced MalignanciesCancer
COMPLETED83 Analytics
PHASE1COMPLETED
AZD8330 First Time in Man in Patients With Advanced Malignancies
CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

To assess safety and tolerability of AZD8330 in patient with advanced malignancies.
Outcome variables: Adverse Events, Clinical Chemistry, Haematology, Urinalysis, Vital signs, MUGA scans/echocardiography, ECGs, Ophthalmologic examination, O2 saturation

Secondary Endpoints

To determine the PK of AZD8330.
To investigate possible PD/PK relationships
To investigate effect of AZD8330 on pERK in PBMCs
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
AZD8330DRUGoral tablet
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites3

Inclusion Criteria: * Cancer which is refractory to standard therapies, or no therapies exist; Exclusion Criteria: * Participated in radiotherapy, biological or chemotherapy within 21 days prior to study start; * Hasn't participated in investigation drug study within 30 days; * Brain metastases/s...

Countries:United StatesNorway
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Frequently asked questions about AZD8330

What is AZD8330 used for?

AZD8330 is an investigational small molecule being studied for the treatment of cancer. It is in Phase 1 clinical development, meaning it is still being tested in humans and has not been approved for any use.

Who makes AZD8330?

AZD8330 is being developed by AstraZeneca PLC, a biopharmaceutical company listed on the stock exchange under the ticker AZN.

What phase is AZD8330 in?

AZD8330 is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. Its only clinical trial, a first-in-human study, has been completed.

What clinical trials is AZD8330 in?

AZD8330 has one completed clinical trial, identified as NCT00454090, titled "AZD8330 First Time in Man in Patients With Advanced Malignancies." This Phase 1 study enrolled 83 patients with cancer in the United States and Norway.

Is AZD8330 FDA approved?

AZD8330 is not FDA approved. It is an investigational drug that has completed a Phase 1 clinical trial, but it remains in clinical development and has not been authorized for marketing.