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AZD2820

Phase 1

Undisclosed | Small molecule | Other |AstraZeneca PLC|Trials Updated: Nov 21, 2011

AZD2820 development status

Highest phase Phase 1
Registered trials 2 across 1 sponsor since Apr 2011

Success Probability

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Market & Valuation

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Trial Design

RandomizedPLACEBO_CONTROLLED
Total Trials1
Total Enrollment90

FDA Designations

No designations recorded

AZD2820 clinical trials

AZD2820 · 1 trial · 1 indication

Phase 1 1
NCT01332214To Assess the Safety, Tolerability and Pharmacokinetics of AZD2820 After Single Ascending DosesHealthy
COMPLETED90 Analytics
PHASE1COMPLETED
To Assess the Safety, Tolerability and Pharmacokinetics of AZD2820 After Single Ascending Doses
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Study Endpoints

Primary Endpoints

Safety variables ( Adverse events, Vital signs, ECG, EEG, Regiscan, Safety labs.)
Assessments performed multilpe times from the morning day 1 before dose until day 3. And then once at the follow up after 14-18 days

Secondary Endpoints

To evaluate the pharmacokinetics of AZD2820 and assess the dose proportionality of the pharmacokinetics following single ascending doses of AZD2820 by assessment Cmax, tmax, t1/2 , AUC, CL/F, Ae and CLR.
Blood samples will be taken multiple times from the morning day 1 before dose until day 2
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Study Design & Arms

AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
AZD2820EXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -

Interventions

NameTypeDescription
AZD2820DRUGSubcutaneous Injection in abdomen or Thigh
PlaceboDRUGSubcutaneous Injection in abdomen or Thigh
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Eligibility Criteria

Age Range20 Years to 45 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Provision of signed and dated, written informed consent prior to any study specific procedures. * Healthy male subjects aged ≥20 - ≤45 years with suitable veins for cannulation or repeated venepuncture. * Male subjects should be willing to use barrier contraception ie, condoms...

Countries:United Kingdom
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Frequently asked questions about AZD2820

What is AZD2820?

AZD2820 is an investigational small molecule developed by AstraZeneca PLC. It has been studied in a Phase 1 clinical trial in healthy male volunteers in the United Kingdom. The specific disease or condition it is intended to treat has not been disclosed.

Who is developing AZD2820?

AZD2820 is being developed by AstraZeneca PLC, which trades under the ticker AZN. AstraZeneca sponsored the Phase 1 trial of the compound conducted in the United Kingdom.

What phase is AZD2820 in?

AZD2820 is in Phase 1 clinical development. One Phase 1 trial has been completed, and no active trials are currently listed. The compound has not been approved by the FDA and remains investigational.

What clinical trials is AZD2820 in?

AZD2820 has been evaluated in one completed Phase 1 trial, NCT01332214, titled a study to assess the safety, tolerability and pharmacokinetics of AZD2820 after single ascending doses. The trial enrolled 90 healthy male volunteers in the United Kingdom and was placebo-controlled and randomized.

What was the design of the AZD2820 Phase 1 trial?

The AZD2820 Phase 1 trial NCT01332214 was a randomized, placebo-controlled, single ascending dose study. It enrolled 90 healthy male volunteers aged 20 years and older in the United Kingdom and assessed safety, tolerability and pharmacokinetics. The trial is completed.