Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT00759395 | Study of Antidepressant Efficacy of a Selective, High Affinity Enkephalinergic Agonist in Anxious Major Depressive Disorder (AMDD) | PHASE2 | COMPLETED | 22 | — | — | Jan 1, 2009 | Oct 1, 2011 | Nov 8, 2012 | 1 | United States |
Hamilton Rating Scale for Depression (HAM-D)is a 17-item, clinician-rated scale that assesses depressive symptoms. The HAMD-17 consists of 17 symptoms, each of which is rated from 0 to 2 or 0 to 4, where 0 is none/absent. The HAMD-17 total score is calculated as the sum of the 17 individual symptom scores; the total score can range from 0 to 52. Higher HAMD-17 scores indicate more severe depression.
The Hamilton Rating Scale for Anxiety (HAM-A) is used as a rating measure of anxiety severity. The scale consists of 14 items. Each item is rated on a scale of 0 to 4. The HAM-A total score is the sum of the 14 items and the score ranges from 0 to 56, 0 is considered the best outcome.
| Arm | Type | Description |
|---|---|---|
| AZD2327 | EXPERIMENTAL | AZD2327 3mg BID |
| Placebo | PLACEBO_COMPARATOR | Placebo BID |
| Name | Type | Description |
|---|---|---|
| AZD2327 | DRUG | Tablet, Oral, Daily |
| Placebo | DRUG | Tablet, Oral, Daily |
Inclusion Criteria: * Provision of informed consent prior to any study specific procedures * Diagnosis of major depressive disorder without psychotic features (MDD) Exclusion Criteria: * A history of substance or alcohol abuse within the past 6 months or dependence within 1 year of enrollment as ...